{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T02:24:04Z","timestamp":1768789444440,"version":"3.49.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,29]],"date-time":"2014-03-29T00:00:00Z","timestamp":1396051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Takeda Italia Farmaceutici"},{"name":"Roche Diagnostics"},{"name":"European Commission's Seventh Framework Programme","award":["305507"],"award-info":[{"award-number":["305507"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Fibroblast growth factor\u201023 (<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023) and vitamin D are hormones involved in phosphate homoeostasis. They also directly influence cardiomyocyte hypertrophy. We examined whether the relationships between levels of vitamin D or <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023, cardiac phenotype and outcome were independent of established cardiac biomarkers in a large cohort of community\u2010dwelling elderly subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Setting<\/jats:title><jats:p>Plasma levels of <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023 and vitamin D were measured in 1851 men and women (65\u201384 years) resident in the Lazio region of Italy. Participants were referred to eight cardiology centres for clinical examination, electrocardiography, comprehensive Doppler echocardiography and blood sampling. All\u2010cause mortality or hospitalizations were available after a median follow\u2010up of 47\u00a0months with record linkage of administrative data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vitamin\u00a0D deficiency (&lt;20\u00a0ng\u00a0mL<jats:sup>\u22121<\/jats:sup>) was found in 72.3% of subjects, but FGF\u201023 levels were normal [74 (58\u201397) RU per mL]. After adjustment for cardiovascular risk factors and morbidities, low concentrations of vitamin D and high levels of FGF\u201023 were associated with a higher left ventricular (LV) mass index. Levels of FGF\u201023 [hazard ratio (HR) (95% confidence interval (CI)) 1.71 (1.28\u20132.28), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001] but not vitamin D [0.76 (0.57\u20131.01), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.08] were independently associated with mortality after adjustment for clinical risk factors and two cardiac markers together (N\u2010terminal pro\u2010brain natriuretic peptide and high\u2010sensitivity cardiac troponin T), but did not predict hospital admission. People with above median values of FGF\u201023 and below median values of vitamin D had greater LV hypertrophy and higher mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In community\u2010dwelling elderly individuals with highly prevalent vitamin\u00a0D deficiency, <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u201023 levels were associated with <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> hypertrophy and predicted mortality independently of two robust cardiac biomarkers. A causal relationship was not demonstrated, but the hormones involved in mineral metabolism emerged as nontraditional risk factors and may affect cardiovascular risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12232","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T17:44:41Z","timestamp":1394646281000},"page":"318-330","source":"Crossref","is-referenced-by-count":30,"title":["The fibroblast growth factor\u201023 and Vitamin D emerge as nontraditional risk factors and may affect cardiovascular risk"],"prefix":"10.1111","volume":"277","author":[{"given":"S.","family":"Masson","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Research IRCCS\u2013Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Agabiti","sequence":"additional","affiliation":[{"name":"Lazio Regional Health Service Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Vago","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrinology Ospedale Luigi Sacco Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Miceli","sequence":"additional","affiliation":[{"name":"ASL Roma D Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Mayer","sequence":"additional","affiliation":[{"name":"Lazio Regional Health Service Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Letizia","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrinology Ospedale Luigi Sacco Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Wienhues\u2010Thelen","sequence":"additional","affiliation":[{"name":"Roche Diagnostics Penzberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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