{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:46:28Z","timestamp":1792676788774,"version":"4.5.0"},"reference-count":143,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T00:00:00Z","timestamp":1399939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alpha\u20101 antitrypsin (\n                    <jats:styled-content style=\"fixed-case\">AAT<\/jats:styled-content>\n                    ) deficiency is an under\u2010recognized hereditary disorder associated with the premature onset of chronic obstructive pulmonary disease, liver cirrhosis in children and adults, and less frequently, relapsing panniculitis, systemic vasculitis and other inflammatory, autoimmune and neoplastic diseases. Severe\n                    <jats:styled-content style=\"fixed-case\">AAT<\/jats:styled-content>\n                    deficiency mainly affects Caucasian individuals and has its highest prevalence (1\u00a0:\u00a02000\u20131\u00a0:\u00a05000 individuals) in Northern, Western and Central Europe. In the\n                    <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>\n                    and Canada, the prevalence is 1: 5000\u201310\u00a0000. Prevalence is five times lower in Latin American countries and is rare or nonexistent in African and Asian individuals. The key to successful diagnosis is by measuring serum\n                    <jats:styled-content style=\"fixed-case\">AAT<\/jats:styled-content>\n                    , followed by the determination of the phenotype or genotype if low concentrations are found. Case detection allows implementation of genetic counselling and, in selected cases, the application of augmentation therapy. Over the past decade, it has been demonstrated that\n                    <jats:styled-content style=\"fixed-case\">AAT<\/jats:styled-content>\n                    is a broad\u2010spectrum anti\u2010inflammatory, immunomodulatory, anti\u2010infective and tissue\u2010repair molecule. These new capacities are promoting an increasing number of clinical studies, new pharmacological formulations, new patent applications and the search for alternative sources of\n                    <jats:styled-content style=\"fixed-case\">AAT<\/jats:styled-content>\n                    (including transgenic and recombinant\n                    <jats:styled-content style=\"fixed-case\">AAT<\/jats:styled-content>\n                    ) to meet the expected demand for treating a large number of diseases, inside and outside the context of\n                    <jats:styled-content style=\"fixed-case\">AAT<\/jats:styled-content>\n                    deficiency.\n                  <\/jats:p>","DOI":"10.1111\/joim.12239","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T23:11:35Z","timestamp":1395702695000},"page":"311-335","source":"Crossref","is-referenced-by-count":208,"title":["Role of alpha\u20101 antitrypsin in human health and disease"],"prefix":"10.1111","volume":"276","author":[{"given":"F.","family":"de Serres","sequence":"first","affiliation":[{"name":"Center for the Evaluation of Risks to Human Reproduction National Toxicology Program National Institute of Environmental Health Sciences Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Blanco","sequence":"additional","affiliation":[{"name":"Board of Directors of the Alpha1\u2010Antitrypsin Deficiency Spanish Registry Lung Foundation Breathe Spanish Society of Pneumology (SEPAR) Provenza Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,13]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02216836"},{"key":"e_1_2_15_3_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1515\/znb-1955-0810","article-title":"Zur Kenntnis der alpha\u2010globulin des menschlichen nirmal serums","volume":"10","author":"Schultze HE","year":"1995","journal-title":"Z Naturforsch"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365516309051324"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1964.tb00567.x"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(65)90184-1"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(67)90181-7"},{"key":"e_1_2_15_8_1","first-page":"153","article-title":"The Pi\u2010system, genetic variants of serum 1 antitrypsin","volume":"151","author":"Fagerhol MK","year":"1968","journal-title":"Ser Haematol"},{"key":"e_1_2_15_9_1","first-page":"934","article-title":"Cirrhosis associated with alpha\u20101\u2010antitrypsin deficiency: a previously unrecognized inherited disorder","volume":"73","author":"Sharp HL","year":"1969","journal-title":"J Lab Clin Med"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.165.3894.709"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.128.5.1137"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197212212872502"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/62.6.732"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(76)90271-3"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90327-4"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197606102942404"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840220221"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.12.021"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6092.922"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1978.tb08452.x"},{"key":"e_1_2_15_21_1","first-page":"660","article-title":"Genetic variation in alpha\u20101\u2010antitrypsin","volume":"30","author":"Cox DW","year":"1978","journal-title":"Am J Hum Genet"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00287070"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00316a003"},{"key":"e_1_2_15_24_1","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1002\/j.1460-2075.1987.tb02571.x","article-title":"The human alpha 1\u2010antitrypsin gene is transcribed from two different promoters in macrophages and hepatocytes","volume":"6","author":"Perlino E","year":"1987","journal-title":"EMBO J"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110360"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03330140013005"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198704233161704"},{"key":"e_1_2_15_28_1","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1001\/jama.1988.03410090091037","article-title":"Biochemical efficacy and safety of monthly augmentation therapy for alpha 1\u2010antitrypsin deficiency","volume":"260","author":"Hubbard RC","year":"1988","journal-title":"JAMA"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.168.7.818"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-0564"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2000.0851"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66781-5"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201108-1428CI"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/357605a0"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004785107"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.6.8970361"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.2.394"},{"key":"e_1_2_15_38_1","first-page":"526","article-title":"A review of the alpha\u20101 foundation: its formation, impact, and critical success factors","volume":"51","author":"Walsh JW","year":"2006","journal-title":"Respir Care"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2013.763783"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00053606"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2013.765838"},{"key":"e_1_2_15_42_1","first-page":"393","article-title":"Development and results of the Spanish registry of patients with alpha\u20101\u2010antitrypsin deficiency","volume":"2","author":"Lara B","year":"2007","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(98)90278-5"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.2003.006494"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.5.1818"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00062305"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.7434"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753465812457113"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.4081\/monaldi.2005.630"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/15412550600829257"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753465810365158"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2010-0328OC"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62261-4"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.060058"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.F250"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/140.6.1662"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.02.002"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(01)00025-4"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0208145"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41196"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-14"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2011.00196"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2012.717125"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2012.09.018"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10424"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2013.764978"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2010.009297"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1190354"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1008007"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2012.758698"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.52.070183.003255"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109013"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01512.x"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.02.190"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)61505-X"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00087-8"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2013.763782"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.153569"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770900701540028"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200703-489OC"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2013.764404"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/920918"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2013.765839"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes233"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23744"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0187"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.5.1537"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0107OC"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.1.9812131"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.022541"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0746"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00135704"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042728"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753465811434320"},{"key":"e_1_2_15_95_1","first-page":"397","article-title":"Alpha 1\u2010antitrypsin deficiency: memorandum from a WHO meeting","volume":"75","year":"1997","journal-title":"Bull World Health Organ"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10102260"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.1.9712017"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.3.737"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S8577"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.5.9901055"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00159408"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1080\/15412550902905961"},{"issue":"7","key":"e_1_2_15_103_1","first-page":"CD007851","article-title":"Intravenous alpha\u20101 antitrypsin augmentation therapy for treating patients with alpha\u20101 antitrypsin deficiency and lung disease","author":"G\u00f8tzsche PC","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-11-136"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.5.1480"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753465812438387"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.5.1425"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1309648110"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/2.2.163"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115391"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(92)80156-B"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.1159\/000196405"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20345"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00047306"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(09)60100-4"},{"key":"e_1_2_15_116_1","first-page":"822","article-title":"Inhibition of histamine release from human mast cells by natural chymase inhibitors","volume":"25","author":"He SH","year":"2004","journal-title":"Acta Pharmacol Sin"},{"key":"e_1_2_15_117_1","first-page":"205","article-title":"Modulation of tryptase and histamine release from human lung mast cells by protease inhibitors","volume":"22","author":"He S","year":"2004","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_15_118_1","first-page":"178","article-title":"Long\u2010term augmentation therapy with alpha\u20101 antitrypsin in an MZ\u2010AAT severe persistent asthma","volume":"69","author":"Blanco I","year":"2008","journal-title":"Monaldi Arch Chest Dis"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.4161\/isl.2.3.11654"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-365247"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-273417"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117665109"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2011.00145"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(94)90364-6"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1474-7"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2012.03.001"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.1409"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2005.06.009"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-9-21"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0311com"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.02.042"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001697"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.11.587"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.05.003"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1089\/10430340050015338"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2006.17.1177"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904514106"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1113400"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4320(03)00169-6"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-005-0324-4"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.4866"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2013.765840"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200602-197ST"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.1.174"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoim.12239","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoim.12239","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.12239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T04:42:14Z","timestamp":1695444134000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.12239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,13]]},"references-count":143,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/joim.12239"],"URL":"https:\/\/doi.org\/10.1111\/joim.12239","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,13]]}}}