{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:40:56Z","timestamp":1790617256294,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T00:00:00Z","timestamp":1400803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous meta\u2010analyses to determine the efficacy of vitamin D supplementation to prevent falls in the elderly have shown mixed results. Inconsistencies might depend on the dose of supplements, suggesting that serum 25\u2010hydroxyvitamin D (25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>) concentration could influence the risk of falling. Our objective was to systematically review and quantitatively analyse the relationship between serum 25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>concentration and the occurrence of falls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A Medline search was conducted in December 2013, with no date limit, using the Medical Subject Heading terms \u2018Vitamin D\u2019<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2018Ergocalciferols\u2019<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2018Vitamin D deficiency\u2019 combined with \u2018Accidental Falls\u2019<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2018Gait disorders, neurologic\u2019<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2018Gait apraxia\u2019<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2018Gait\u2019<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2018Recurrent Falls\u2019<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2018Falling\u2019. Fixed and random\u2010effects meta\u2010analyses were performed to determine the following: (i) the effect size of the difference in 25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>concentration between fallers and nonfallers and (ii) the risk of falling according to serum 25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 659 retrieved studies, 18 observational studies \u2013 including ten cross\u2010sectional and eight cohort studies \u2013 met the selection criteria. All were of good quality. The number of participants ranged from 80 to 2957 (44\u2013100% women); 11.0% to 69.3% were fallers. Serum 25OHD concentrations were 0.33\u00a0\u00d7\u00a0SD lower in fallers compared to nonfallers [pooled effect size 0.33; 95% confidence interval (CI) 0.18\u20130.47]. The risk of falls was inversely associated with serum 25OHD concentration [summary odds ratio (OR) 0.97; 95% CI 0.96\u20130.99]. The association between falls and hypovitaminosis D varied according to the definition used; the summary OR for falls was 1.23 (95% CI 0.94\u20131.60) for 25OHD &lt;10\u00a0ng\u00a0mL<jats:sup>\u22121<\/jats:sup>, 1.44 (95% CI 1.17\u20131.76) for 25OHD &lt;20\u00a0ng\u00a0mL<jats:sup>\u22121<\/jats:sup>and 0.95 (95% CI 0.81\u20131.11) for 25OHD &lt;30\u00a0ng\u00a0mL<jats:sup>\u22121<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fallers have lower 25OHD concentrations, notably more often &lt;20\u00a0ng\u00a0mL<jats:sup>\u22121<\/jats:sup>, than nonfallers. These findings help to determine the profile of target populations that would most benefit from vitamin D supplements to prevent falls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12250","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T06:57:00Z","timestamp":1396594620000},"page":"16-44","source":"Crossref","is-referenced-by-count":36,"title":["Questioning vitamin D status of elderly fallers and nonfallers: a meta\u2010analysis to address a \u2018forgotten step\u2019"],"prefix":"10.1111","volume":"277","author":[{"given":"C.","family":"Annweiler","sequence":"first","affiliation":[{"name":"Department of Neuroscience Division of Geriatric Medicine and Memory Clinic Angers University Hospital and UPRES EA 4638 University of Angers, UNAM Angers France"},{"name":"Robarts Research Institute The University of Western Ontario London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Beauchet","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Division of Geriatric Medicine and Memory Clinic Angers University Hospital and UPRES EA 4638 University of Angers, UNAM Angers France"},{"name":"Biomathics Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,23]]},"reference":[{"key":"e_1_2_11_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.05.011"},{"key":"e_1_2_11_1_3_1","first-page":"259","article-title":"Vitamin D in the elderly: 5 points to remember","volume":"9","author":"Annweiler C","year":"2011","journal-title":"Geriatr Psychol Neuropsychiatr Vieil"},{"key":"e_1_2_11_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b3692"},{"key":"e_1_2_11_1_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-0003-7-50"},{"key":"e_1_2_11_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.18.2257"},{"key":"e_1_2_11_1_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4394"},{"key":"e_1_2_11_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1999.tb05199.x"},{"key":"e_1_2_11_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1999.tb04581.x"},{"key":"e_1_2_11_1_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-14831"},{"key":"e_1_2_11_1_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2003.51510.x"},{"key":"e_1_2_11_1_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031782"},{"key":"e_1_2_11_1_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2364"},{"key":"e_1_2_11_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0071-8"},{"key":"e_1_2_11_1_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0510"},{"key":"e_1_2_11_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0582-6"},{"key":"e_1_2_11_1_17_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080328"},{"key":"e_1_2_11_1_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000207356"},{"key":"e_1_2_11_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-009-0910-5"},{"key":"e_1_2_11_1_20_1","first-page":"142","article-title":"Fall predictors in the community dwelling elderly: a cross sectional and prospective cohort study","volume":"10","author":"Sai AJ","year":"2010","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_11_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2010.03.004"},{"key":"e_1_2_11_1_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318219fb08"},{"key":"e_1_2_11_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1637-7"},{"key":"e_1_2_11_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-012-0378-4"},{"key":"e_1_2_11_1_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12201"},{"key":"e_1_2_11_1_26_1","volume-title":"3rd Symposium on Systematic Reviews: Beyond the Basics","author":"Wells GA"},{"key":"e_1_2_11_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470693926"},{"key":"e_1_2_11_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-4825(00)00006-8"},{"key":"e_1_2_11_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_11_1_30_1","doi-asserted-by":"publisher","DOI":"10.4135\/9781412984980"},{"key":"e_1_2_11_1_31_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03200750"},{"key":"e_1_2_11_1_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1975.tb01358.x"},{"key":"e_1_2_11_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2008.07.002"},{"key":"e_1_2_11_1_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040622310381934"},{"key":"e_1_2_11_1_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03733.x"},{"key":"e_1_2_11_1_36_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28113"},{"key":"e_1_2_11_1_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339702"},{"key":"e_1_2_11_1_38_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-130452"},{"key":"e_1_2_11_1_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328010ca18"},{"key":"e_1_2_11_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00303-3"},{"key":"e_1_2_11_1_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000318570"},{"key":"e_1_2_11_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2011.05.009"},{"key":"e_1_2_11_1_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087314"},{"key":"e_1_2_11_1_44_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/BF03654796","article-title":"Hypovitaminosis D in geriatric inpatients: a marker of severity of chronic diseases","volume":"24","author":"Beauchet O","year":"2012","journal-title":"Aging Clin Exp Res"},{"key":"e_1_2_11_1_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.594"},{"key":"e_1_2_11_1_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.03201.x"},{"key":"e_1_2_11_1_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2317"},{"key":"e_1_2_11_1_48_1","volume-title":"Prevention and Management of Osteoporosis: Report of a WHO Scientific Group","author":"World Health Organization","year":"2003"},{"key":"e_1_2_11_1_49_1","volume-title":"Dietary Reference Intakes for Calcium and Vitamin D. Committee to Review Dietary Reference Intakes for Calcium and Vitamin D","author":"Institute of Medicine","year":"2011"},{"key":"e_1_2_11_1_50_1","volume-title":"Global Report on Falls Prevention in Older Age","author":"World Health Organization","year":"2007"},{"key":"e_1_2_11_1_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1988.tb06155.x"},{"key":"e_1_2_11_1_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afi218"},{"key":"e_1_2_11_1_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afh209"},{"key":"e_1_2_11_1_54_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.2.343"},{"key":"e_1_2_11_1_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afh002"},{"key":"e_1_2_11_1_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afm087"},{"key":"e_1_2_11_1_57_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7387.469"},{"key":"e_1_2_11_1_58_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.8.7703"},{"key":"e_1_2_11_1_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52060.x"},{"key":"e_1_2_11_1_60_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1195"},{"key":"e_1_2_11_1_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0374-4"},{"key":"e_1_2_11_1_62_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.212.275"},{"key":"e_1_2_11_1_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0258(20001130)19:22<3127::AID-SIM784>3.0.CO;2-M"},{"key":"e_1_2_11_1_64_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d549"},{"key":"e_1_2_11_1_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/nure.12090"},{"key":"e_1_2_11_1_66_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.19833"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoim.12250","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoim.12250","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.12250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T17:01:17Z","timestamp":1716656477000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.12250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,23]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/joim.12250"],"URL":"https:\/\/doi.org\/10.1111\/joim.12250","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,23]]}}}