{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:17:06Z","timestamp":1777630626985,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T00:00:00Z","timestamp":1400198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Liver\u2010selective thyromimetic agents could provide a new approach for treating dyslipidaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a multicentre, randomized, placebo\u2010controlled, double\u2010blind study to evaluate the efficacy and safety of eprotirome, a liver\u2010selective thyroid hormone receptor agonist, in 98 patients with primary hypercholesterolaemia. After previous drug wash\u2010out and dietary run\u2010in, patients received 100 or 200\u00a0\u03bcg\u00a0day<jats:sup>\u22121<\/jats:sup> eprotirome or placebo for 12\u00a0weeks. The primary end\u2010point was change in serum <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> cholesterol; secondary end\u2010points included changes in other lipid parameters and safety measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eprotirome treatment at 100 and 200\u00a0\u03bcg daily reduced serum <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> cholesterol levels by 23\u00a0\u00b1\u00a05% and 31\u00a0\u00b1\u00a04%, respectively, compared with 2\u00a0\u00b1\u00a06% for placebo (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). Similar reductions were seen in non\u2010<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> cholesterol and apolipoprotein (apo) B, whereas serum levels of <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> cholesterol and apo A\u2010I were unchanged. There were also considerable reductions in serum triglycerides and lipoprotein(a), in particular in patients with elevated levels at baseline. There was no evidence of adverse effects on heart or bone and no changes in serum thyrotropin or triiodothyronine, although the thyroxine level decreased. Low\u2010grade increases in liver enzymes were evident in most patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In hypercholesterolaemic patients, the liver\u2010selective thyromimetic eprotirome decreased serum levels of atherogenic lipoproteins without signs of extra\u2010hepatic side effects. Selective stimulation of hepatic thyroid hormone receptors may be an attractive way to modulate lipid metabolism in hyperlipidaemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12261","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T04:08:35Z","timestamp":1398226115000},"page":"331-342","source":"Crossref","is-referenced-by-count":45,"title":["Reductions in serum levels of <scp>LDL<\/scp> cholesterol, apolipoprotein B, triglycerides and lipoprotein(a) in hypercholesterolaemic patients treated with the liver\u2010selective thyroid hormone receptor agonist eprotirome"],"prefix":"10.1111","volume":"277","author":[{"given":"Bo","family":"Angelin","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Metabolism and Diabetes Center for Biosciences Karolinska Institutet At Karolinska University Hospital Huddinge Stockholm Sweden"},{"name":"Center for Biosciences Department of Medicine Karolinska Institutet at Karolinska University Hospital Huddinge Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens D.","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Karo Bio AB Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Diabetes Center for Biosciences Karolinska Institutet At Karolinska University Hospital Huddinge Stockholm Sweden"},{"name":"Center for Biosciences Department of Medicine Karolinska Institutet at Karolinska University Hospital Huddinge Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Karo Bio AB Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irwin","family":"Klein","sequence":"additional","affiliation":[{"name":"New York University School of Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders G.","family":"Olsson","sequence":"additional","affiliation":[{"name":"The Faculty of Health Sciences Link\u00f6ping University and Stockholm Heart Center Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Chester Ridgway","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism and Diabetes University of Colorado School of Medicine Aurora CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul W.","family":"Ladenson","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism Department of Medicine The Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0140-6736(05)67394-1","article-title":"Efficacy and safety of cholesterol\u2010lowering treatment: prospective meta\u2010analysis of data from 90 056 participants in14 randomised trials of statins","volume":"366","author":"Cholesterol Treatment Trialists' (CTT) Collaborators","year":"2005","journal-title":"Lancet"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.4.459"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60545-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1063"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.593855"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1001\/jama.1972.03200070084015","article-title":"Findings leading to further modifications of its protocol with respect to dextrothyroxine","volume":"220","author":"The Coronary Drug Project","year":"1972","journal-title":"JAMA"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e3283402e9c"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.4.2591"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)91568-D"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2002-0009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504379102"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M800553-JLR200"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.01.032"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072503321669848"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104066"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.7.2153"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705286104"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905633"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.106.25.3143"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702759104"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1989.tb01245.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2009.11.004"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp070061"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.01.008"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22572"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503139200"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0902604"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e32832f0a5b"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-199712000-00003"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804381"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1183"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61965-6"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70006-3"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(01)00476-4"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend-4-5-743"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoim.12261","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoim.12261","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.12261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T18:36:45Z","timestamp":1696012605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.12261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,16]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/joim.12261"],"URL":"https:\/\/doi.org\/10.1111\/joim.12261","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,16]]}}}