{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:43:03Z","timestamp":1791243783747,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T00:00:00Z","timestamp":1410912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Maribo Medico, Denmark"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognostic significance of age and continuous positive airway pressure (<jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>) therapy on cardiovascular disease in patients with sleep apnoea has not been assessed previously.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using nationwide databases, the entire Danish population was followed from 2000 until 2011. First\u2010time sleep apnoea diagnoses and use of <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> therapy were determined. Incidence rate ratios (<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content>s) of ischaemic stroke and myocardial infarction (<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>) were analysed using Poisson regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Amongst 4.5 million individuals included in the study, 33\u00a0274 developed sleep apnoea (mean age 53, 79% men) of whom 44% received persistent <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> therapy. Median time to initiation of <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> therapy was 88\u00a0days (interquartile range 34\u2013346). Patients with sleep apnoea had more comorbidities compared to the general population. Crude rates of <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> and ischaemic stroke were increased for sleep apnoea patients (5.4 and 3.6 events per 1000 person\u2010years compared to 4.0 and 3.0 in the general population, respectively). Relative to the general population, risk of <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> [<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content> 1.71, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.57\u20131.86] and ischaemic stroke (<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content> 1.50, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.35\u20131.66) was significantly increased in patients with sleep apnoea, in particular in patients younger than 50\u00a0years (<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content> 2.12, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.64\u20132.74 and <jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content> 2.34, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.77\u20133.10, respectively). Subsequent <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> therapy was not associated with altered prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sleep apnoea is associated with increased risk of ischaemic stroke and <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, particularly in patients younger than 50\u00a0years of age. <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> therapy was not associated with a reduced rate of stroke or <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12302","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T15:23:12Z","timestamp":1409239392000},"page":"659-666","source":"Crossref","is-referenced-by-count":44,"title":["Cardiovascular risk in patients with sleep apnoea with or without continuous positive airway pressure therapy: follow\u2010up of 4.5 million Danish adults"],"prefix":"10.1111","volume":"276","author":[{"given":"M.","family":"Lamberts","sequence":"first","affiliation":[{"name":"Department of Cardiology Gentofte University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. W.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bispebjerg University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"University of Birmingham Centre for Cardiovascular Sciences City Hospital Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. H.","family":"Ruwald","sequence":"additional","affiliation":[{"name":"Department of Cardiology Gentofte University Hospital Copenhagen Denmark"},{"name":"Division of Cardiology Heart Research Follow\u2010up Program University of Rochester Medical Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. B.","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Gentofte University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. L.","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Gentofte University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Torp\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Institute of Health Science and Technology Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Gentofte University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. H.","family":"Gislason","sequence":"additional","affiliation":[{"name":"Department of Cardiology Gentofte University Hospital Copenhagen Denmark"},{"name":"National Institute of Public Health University of Southern Denmark Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.16a23.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.51.Suppl_2.S65"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.189420"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs253"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005113421901"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7233.479"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.106.2.466"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.4.1133"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00494.2005"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.2.2005037"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00084905"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.4.447"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d124"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2008.05.006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(02)00591-7"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000102143"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27497"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5664\/jcsm.2398","article-title":"Morbidity prior to a diagnosis of sleep\u2010disordered breathing: a controlled national study","volume":"9","author":"Jennum P","year":"2013","journal-title":"J Clin Sleep Med"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71141-7"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201203-0448OC"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoim.12302","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoim.12302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.12302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T20:20:31Z","timestamp":1696191631000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.12302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,17]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/joim.12302"],"URL":"https:\/\/doi.org\/10.1111\/joim.12302","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,17]]}}}