{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:33:15Z","timestamp":1791419595882,"version":"4.3.3"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T00:00:00Z","timestamp":1420416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\n                      ipoprotein(a) [\n                      <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\n                      p(a)] is an independent risk factor for aortic valve stenosis and aortic valve calcification (\n                      <jats:styled-content style=\"fixed-case\">AVC<\/jats:styled-content>\n                      ) in the general population. In this study, we determined the association between\n                      <jats:styled-content style=\"fixed-case\">AVC<\/jats:styled-content>\n                      and both plasma\n                      <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\n                      p(a) levels and apolipoprotein(a) [apo(a)] kringle\n                      <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                      repeat polymorphisms in asymptomatic statin\u2010treated patients with heterozygous familial hypercholesterolaemia (\n                      <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 129 asymptomatic heterozygous\n                      <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>\n                      patients (age 40\u201369\u00a0years) were included in this study.\n                      <jats:styled-content style=\"fixed-case\">AVC<\/jats:styled-content>\n                      was detected using computed tomography scanning. Lp(a) concentration and apo(a) kringle\n                      <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                      repeat number were measured using immunoturbidimetry and immunoblotting, respectively. Univariate and multivariate logistic regression were used to assess the association between\n                      <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\n                      p(a) concentration and the presence of\n                      <jats:styled-content style=\"fixed-case\">AVC<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Aortic valve calcification was present in 38.2% of patients, including three with extensive\n                      <jats:styled-content style=\"fixed-case\">AVC<\/jats:styled-content>\n                      (&gt;400\u00a0\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      gatston units). Lp(a) concentration was significantly correlated with gender, number of apo(a) kringle\n                      <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n                      repeats and the presence and severity of\n                      <jats:styled-content style=\"fixed-case\">AVC<\/jats:styled-content>\n                      , but not with coronary artery calcification (\n                      <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n                      ).\n                      <jats:styled-content style=\"fixed-case\">AVC<\/jats:styled-content>\n                      was significantly associated with plasma\n                      <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\n                      p(a) level, age, body mass index, blood pressure, duration of statin use, cholesterol\u2010year score and\n                      <jats:styled-content style=\"fixed-case\">CAC<\/jats:styled-content>\n                      score. After adjustment for all significant covariables, plasma\n                      <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\n                      p(a) concentration remained a significant predictor of\n                      <jats:styled-content style=\"fixed-case\">AVC<\/jats:styled-content>\n                      , with an odds ratio per 10\u2010mg\u00a0dL\n                      <jats:sup>\u22121<\/jats:sup>\n                      increase in\n                      <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\n                      p(a) concentration of 1.11 (95% confidence interval 1.01\u20131.20,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In asymptomatic statin\u2010treated\n                      <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>\n                      patients, plasma Lp(a) concentration is an independent risk indicator for\n                      <jats:styled-content style=\"fixed-case\">AVC<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.12335","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T12:37:22Z","timestamp":1418128642000},"page":"166-173","source":"Crossref","is-referenced-by-count":103,"title":["Lipoprotein(a) levels are associated with aortic valve calcification in asymptomatic patients with familial hypercholesterolaemia"],"prefix":"10.1111","volume":"278","author":[{"given":"R.","family":"Vongpromek","sequence":"first","affiliation":[{"name":"Division of Pharmacology Vascular and Metabolic Diseases Department of Internal Medicine Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bos","sequence":"additional","affiliation":[{"name":"Division of Pharmacology Vascular and Metabolic Diseases Department of Internal Medicine Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.\u2010J. 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