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posterior atrophy (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>) scales, respectively. However, practical cut\u2010offs are urgently needed, especially now that different presentations of Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) are included in the revised diagnostic criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to generate a list of practical cut\u2010offs for the <jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> GCA<\/jats:styled-content>\u2010F and <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> scales, for both diagnosis of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and determining prognosis in mild cognitive impairment (<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>), and to evaluate the influence of key demographic and clinical factors on these cut\u2010offs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>AddNeuroMed and <jats:styled-content style=\"fixed-case\">ADNI<\/jats:styled-content> cohorts were combined giving a total of 1147 participants (322 patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, 480 patients with <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content> and 345 control subjects). The <jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> GCA<\/jats:styled-content>\u2010F and <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> scales were applied and a broad range of cut\u2010offs was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content> scale showed better diagnostic and predictive performances than the <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content>\u2010F and <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> scales. Age, apolipoprotein E (<jats:italic>ApoE<\/jats:italic>) \u03b54 status and age at disease onset influenced all three scales. For the age ranges 45\u201364, 65\u201374, 75\u201384 and 85\u201394\u00a0years, the following cut\u2010offs should be used. <jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content>: \u22651.5, \u22651.5, \u22652 and \u22652.5; <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content>\u2010F, \u22651, \u22651, \u22651 and \u22651; and <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>, \u22651, \u22651, \u22651 and \u22651, respectively, with an adjustment for early\u2010onset <jats:italic>ApoE<\/jats:italic> \u03b54 noncarrier <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients (<jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content>: \u22652, \u22652, \u22653 and \u22653; and <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content>\u2010F: \u22651, \u22651, \u22652 and \u22652, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>If successfully validated in clinical settings, the list of practical cut\u2010offs proposed here might be useful in clinical practice. Their use might also (i) promote research on atrophy subtypes, (ii) increase the understanding of different presentations of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, (iii) improve diagnosis and prognosis and (iv) aid population selection and enrichment for clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12358","type":"journal-article","created":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T08:37:00Z","timestamp":1425890220000},"page":"277-290","source":"Crossref","is-referenced-by-count":108,"title":["Practical cut\u2010offs for visual rating scales of medial temporal, frontal and posterior atrophy in <scp>A<\/scp>lzheimer's disease and mild cognitive impairment"],"prefix":"10.1111","volume":"278","author":[{"given":"D.","family":"Ferreira","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society Center for Alzheimer Research Division of Clinical Geriatrics Stockholm 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