{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T07:52:18Z","timestamp":1781941938297,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006483","name":"Abbvie","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Alfred Helsteds og Eli M\u00f8llers Legat"},{"name":"C. C. Klestrup og hustru Henriette Klestrups Mindelegat"},{"name":"Carl og Ellen Hertz legat til dansk laege- og naturvidenskab"},{"name":"Fonden af 1870"},{"name":"Psoriasis Forskningsfonden"},{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with psoriasis have an increased risk of type 2 diabetes. The gastrointestinal system plays a major role in normal glucose metabolism, and in healthy individuals, postprandial insulin secretion is largely mediated by the gut incretin hormones. This potentiation is termed the incretin effect and is reduced in type 2 diabetes. The impact of psoriasis on gastrointestinal factors involved in glucose metabolism has not previously been examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether the incretin effect, gastrointestinal\u2010mediated glucose disposal (<jats:styled-content style=\"fixed-case\">GIGD<\/jats:styled-content>) and\/or secretion of glucagon and gut incretin hormones are impaired in normal glucose\u2010tolerant patients with psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Oral glucose tolerance tests and intravenous isoglycaemic glucose infusions were performed in 12 patients with moderate\u2010to\u2010severe psoriasis and 12 healthy matched control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients with psoriasis, the incretin effect (39% vs. 57%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02) and <jats:styled-content style=\"fixed-case\">GIGD<\/jats:styled-content> (53% vs. 61%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.04) were significantly reduced compared to control subjects. In addition, patients were glucose intolerant and showed exaggerated glucose\u2010dependent insulinotropic polypeptide responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These novel findings support the notion that psoriasis is a prediabetic condition and suggest that gastrointestinal\u2010related mechanisms are involved in the increased susceptibility to type 2 diabetes in patients with psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12388","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T22:19:01Z","timestamp":1436912341000},"page":"660-670","source":"Crossref","is-referenced-by-count":24,"title":["Impaired incretin effect is an early sign of glucose dysmetabolism in nondiabetic patients with psoriasis"],"prefix":"10.1111","volume":"278","author":[{"given":"M.","family":"Gyldenl\u00f8ve","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Allergology Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Vilsb\u00f8ll","sequence":"additional","affiliation":[{"name":"Center for Diabetes Research Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Zachariae","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Holst","sequence":"additional","affiliation":[{"name":"NNF Centre for Basic Metabolic Research Department of Biomedicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. K.","family":"Knop","sequence":"additional","affiliation":[{"name":"Center for Diabetes Research Gentofte Hospital University of Copenhagen Hellerup Denmark"},{"name":"NNF Centre for Basic Metabolic Research Department of Biomedicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamadermatol.406"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12473"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2330"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2008.08.012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02427280"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-s227"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116186"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13789"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.43.4.535"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0266"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115012"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01549.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2337\/diab.41.3.368","article-title":"Estimation of insulin secretion rates from C\u2010peptide levels. 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