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Autoimmunity is known to have a role in myositis pathogenesis, and myositis\u2010specific autoantibodies, targeting important intracellular proteins, are regarded as key biomarkers aiding in the diagnosis of patients. In recent years, a number of novel myositis autoantibodies including anti\u2010\n                    <jats:styled-content style=\"fixed-case\">TIF<\/jats:styled-content>\n                    1, anti\u2010\n                    <jats:styled-content style=\"fixed-case\">NXP<\/jats:styled-content>\n                    2, anti\u2010\n                    <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>\n                    5, anti\u2010\n                    <jats:styled-content style=\"fixed-case\">SAE<\/jats:styled-content>\n                    , anti\u2010\n                    <jats:styled-content style=\"fixed-case\">HMGCR<\/jats:styled-content>\n                    and anti\u2010\n                    <jats:styled-content style=\"fixed-case\">cN<\/jats:styled-content>\n                    1A have been identified in both adult and juvenile patients. These autoantibodies correlate with distinct clinical manifestations and importantly are found in inclusion body, statin\u2010induced, clinically amyopathic and juvenile groups of myositis patients, previously believed to be mainly autoantibody negative. In this review, we will describe the main myositis\u2010specific and myositis\u2010associated autoantibodies and their frequencies and clinical associations across different ages and ethnic groups. We will also discuss preliminary studies investigating correlations between specific myositis autoantibody titres and clinical markers of disease course, collectively demonstrating the utility of myositis autoantibodies as both diagnostic and prognostic markers of disease.\n                  <\/jats:p>","DOI":"10.1111\/joim.12451","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T02:10:23Z","timestamp":1448417423000},"page":"8-23","source":"Crossref","is-referenced-by-count":393,"title":["Myositis\u2010specific autoantibodies: an important tool to support diagnosis of myositis"],"prefix":"10.1111","volume":"280","author":[{"given":"Z.","family":"Betteridge","sequence":"first","affiliation":[{"name":"Department of Pharmacy and Pharmacology University of Bath Bath UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"McHugh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmacology University of Bath Bath UK"},{"name":"Royal National Hospital for Rheumatic Disease Bath UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24566"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13317-011-0018-8"},{"key":"e_1_2_11_4_1","first-page":"1","article-title":"Autoantibodies to extractable nuclear antigens: making detection and interpretation more meaningful","volume":"9","author":"Phan TG","year":"2002","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-013-8387-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-009-0155-3"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5858\/2000-124-0071-GFCUOT","article-title":"Guidelines for clinical use of the antinuclear antibody test and tests for specific autoantibodies to nuclear antigens. 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