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Patients underwent clinical and neuropsychological evaluation, magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>), electroencephalography (<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>) and lumbar puncture to assess the levels of amyloid \u03b2 peptide 1\u201342 (A\u03b242), tau and p\u2010tau, and blood samples were collected. Genetic (<jats:italic><jats:styled-content style=\"fixed-case\">APOE<\/jats:styled-content><\/jats:italic>), neuroimaging (3T morphometry and diffusion<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) and<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>(with resting\u2010state and auditory oddball event\u2010related potential (<jats:styled-content style=\"fixed-case\">AO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ERP<\/jats:styled-content>) paradigm) biomarkers were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prodromal<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>was found in 55<jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content>patients defined by low A\u03b242 in the cerebrospinal fluid (A\u03b2 positive). Compared to the<jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content>group with high A\u03b242 levels (A\u03b2 negative), A\u03b2 positive patients showed poorer visual (<jats:italic>P<\/jats:italic>= 0.001), spatial recognition (<jats:italic>P<\/jats:italic>&lt; 0.0005) and working (<jats:italic>P<\/jats:italic>= 0.024) memory, as well as a higher frequency of<jats:italic><jats:styled-content style=\"fixed-case\">APOE<\/jats:styled-content><\/jats:italic>4 (<jats:italic>P<\/jats:italic>&lt; 0.0005), lower hippocampal volume (<jats:italic>P<\/jats:italic>= 0.04), reduced thickness of the parietal cortex (<jats:italic>P<\/jats:italic>&lt; 0.009) and structural connectivity of the corpus callosum (<jats:italic>P<\/jats:italic>&lt; 0.05), higher amplitude of delta rhythms at rest (<jats:italic>P<\/jats:italic>= 0.03) and lower amplitude of posterior cingulate sources of<jats:styled-content style=\"fixed-case\">AO<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ERP<\/jats:styled-content>(<jats:italic>P<\/jats:italic>= 0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that, in<jats:styled-content style=\"fixed-case\">aMCI<\/jats:styled-content>patients, prodromal<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>is characterized by a distinctive cognitive profile and genetic, neuroimaging and neurophysiological biomarkers. Longitudinal assessment will help to identify the role of these biomarkers in<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12482","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T16:19:45Z","timestamp":1457194785000},"page":"576-591","source":"Crossref","is-referenced-by-count":78,"title":["Clinical and biomarker profiling of prodromal Alzheimer's disease in workpackage 5 of the Innovative Medicines Initiative PharmaCog project: a \u2018European<scp>ADNI<\/scp>study\u2019"],"prefix":"10.1111","volume":"279","author":[{"given":"S.","family":"Galluzzi","sequence":"first","affiliation":[{"name":"Laboratory of Alzheimer's Neuroimaging &amp; Epidemiology Saint John of God Clinical Research Centre Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Marizzoni","sequence":"additional","affiliation":[{"name":"Laboratory of Alzheimer's Neuroimaging &amp; Epidemiology Saint John of God Clinical Research Centre Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Babiloni","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology University of Rome \u2018La Sapienza\u2019 Rome Italy"},{"name":"IRCCS San Raffaele Pisana of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Albani","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Mario Negri Institute for Pharmacological Research Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Antelmi","sequence":"additional","affiliation":[{"name":"Laboratory of Alzheimer's Neuroimaging &amp; Epidemiology Saint John of God Clinical Research Centre Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bagnoli","sequence":"additional","affiliation":[{"name":"Laboratory of Alzheimer's Neuroimaging &amp; Epidemiology Saint John of God Clinical Research Centre Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bartres\u2010Faz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine University of Barcelona and Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Catalunya Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cordone","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology University of Rome \u2018La Sapienza\u2019 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Didic","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, INSERM Marseille France"},{"name":"Service de Neurologie et Neuropsychologie APHM H\u00f4pital Timone Adultes Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Farotti","sequence":"additional","affiliation":[{"name":"Clinica Neurologica Universit\u00e0 di Perugia, Ospedale Santa Maria della Misericordia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Fiedler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Faculty of Medicine LVR\u2010Hospital Essen, University of Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Forloni","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Mario Negri Institute for Pharmacological Research Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Girtler","sequence":"additional","affiliation":[{"name":"Clinical Neurology, Department of Neurosciences, Rehabilitation, Ophthalmology and Maternal\u2010Fetal Medicine University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Hensch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Jovicich","sequence":"additional","affiliation":[{"name":"Center for Mind\/Brain Sciences University of Trento Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Leeuwis","sequence":"additional","affiliation":[{"name":"Department of Neurology Alzheimer Centre, VU Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Marra","sequence":"additional","affiliation":[{"name":"Department of Gerontology, Neurosciences &amp; Orthopedics Catholic University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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