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Many pathologies are directly and indirectly related to vascular dysfunction, which causes significant morbidity and mortality. A common pathophysiological feature of diseased vessels is extracellular matrix (\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    ) remodelling. Analysing the protein composition of the\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    by conventional antibody\u2010based techniques is challenging; alternative splicing or post\u2010translational modifications, such as glycosylation, can mask epitopes required for antibody recognition. By contrast, proteomic analysis by mass spectrometry enables the study of proteins without the constraints of antibodies. Recent advances in proteomic techniques make it feasible to characterize the composition of the vascular\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    and its remodelling in disease. These developments may lead to the discovery of novel prognostic and diagnostic markers. Thus, proteomics holds potential for identifying\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    signatures to monitor vascular disease processes. Furthermore, a better understanding of the\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    remodelling processes in the vasculature might make\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    \u2010associated proteins more attractive targets for drug discovery efforts. In this review, we will summarize the role of the\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    in the vasculature. Then, we will describe the challenges associated with studying the intricate network of\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    proteins and the current proteomic strategies to analyse the vascular\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    in metabolic and cardiovascular diseases.\n                  <\/jats:p>","DOI":"10.1111\/joim.12486","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T11:18:46Z","timestamp":1457176726000},"page":"325-338","source":"Crossref","is-referenced-by-count":52,"title":["Vascular proteomics in metabolic and cardiovascular diseases"],"prefix":"10.1111","volume":"280","author":[{"given":"M.","family":"Lynch","sequence":"first","affiliation":[{"name":"King's British Heart Foundation Centre King's College London London 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