{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:13:24Z","timestamp":1790777604275,"version":"4.1.0"},"reference-count":81,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T00:00:00Z","timestamp":1458604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There are around 30 human diseases associated with protein misfolding and amyloid formation, each one caused by a certain protein or peptide. Many of these diseases are lethal and together they pose an enormous burden to society. The prion protein has attracted particular interest as being shown to be the pathogenic agent in transmissible diseases such as kuru, Creutzfeldt\u2013Jakob disease and bovine spongiform encephalopathy. Whether similar transmission could occur also in other amyloidoses such as Alzheimer's disease, Parkinson's disease and serum amyloid A amyloidosis is a matter of intense research and debate. Furthermore, it has been suggested that novel biomaterials such as artificial spider silk are potentially amyloidogenic. Here, we provide a brief introduction to amyloid, prions and other proteins involved in amyloid disease and review recent evidence for their potential transmission. We discuss the similarities and differences between amyloid and silk, as well as the potential hazards associated with protein\u2010based biomaterials.<\/jats:p>","DOI":"10.1111\/joim.12499","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T12:15:11Z","timestamp":1458648911000},"page":"153-163","source":"Crossref","is-referenced-by-count":22,"title":["Transmissible amyloid"],"prefix":"10.1111","volume":"280","author":[{"given":"L.O.","family":"Tjernberg","sequence":"first","affiliation":[{"name":"Department of Neurobiology Care Sciences and Society Division of Neurogeriatrics Center for Alzheimer Research Karolinska Institutet Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rising","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Care Sciences and Society Division of Neurogeriatrics Center for Alzheimer Research Karolinska Institutet Huddinge Sweden"},{"name":"Department of Anatomy, Physiology and Biochemistry Swedish University of Agricultural Sciences Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Care Sciences and Society Division of Neurogeriatrics Center for Alzheimer Research Karolinska Institutet Huddinge Sweden"},{"name":"Department of Anatomy, Physiology and Biochemistry Swedish University of Agricultural Sciences Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Jaudzems","sequence":"additional","affiliation":[{"name":"Latvian Institute of Organic Synthesis Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Westermark","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,22]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406847102"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03680"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.05024.x"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00164a008"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.092205999"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.5.2558"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780257"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501814102"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.11.016"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311300200"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006041"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195711142572005"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91958-4"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197403212901220"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6801762"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90168-X"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.7.2214"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3014653"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91412-9"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(84)80190-4"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.12.4245"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.16.7437"},{"key":"e_1_2_14_24_1","first-page":"441","article-title":"Evidence for the experimental transmission of cerebral beta\u2010amyloidosis to primates","volume":"74","author":"Baker HF","year":"1993","journal-title":"Int J Exp Pathol"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194516"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15369"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.23.11282"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.161"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1747"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322357111"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-020712-163913"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.08.004"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079104"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2013.876400"},{"key":"e_1_2_14_35_1","first-page":"1","article-title":"Experimentelle Amyloidose bei splenektomierten M\u00e4usen","volume":"140","author":"Dreher R","year":"1970","journal-title":"Z Immunit\u00e4tsforsch Allerg klin Immunol"},{"key":"e_1_2_14_36_1","first-page":"53","article-title":"Kinetics of amyloid deposition. I. The effects of amyloid\u2010enhancing factor and splenectomy","volume":"48","author":"Kisilevsky R","year":"1983","journal-title":"Lab Invest"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506120500106941"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800367105"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506120903090759"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113765"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2013.783474"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813511128"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0901-976"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80106-3"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.60.080805.142106"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003308"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506120802676831"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700848104"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(96)79539-5"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja8021208"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5245.84"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2002.03112.x"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/35069000"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1042\/bss0680001"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(08)60320-4"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm049717v"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(99)01445-0"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2014.964858"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.12.2413"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000514"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.02.040"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.1078"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08962"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08936"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001921"},{"key":"e_1_2_14_66_1","first-page":"12","article-title":"Comparative Silk Protein Expression of Different Hybrid Varieties of Bombyx mori","volume":"1","author":"Sabina A","year":"2012","journal-title":"Trends in Life Sci"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.10.062"},{"key":"e_1_2_14_68_1","first-page":"455","volume-title":"Amyloid Fibrils and Prefibrillar Aggregates Molecular and Biological Properties","author":"Johansson J"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1789"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10858-012-9679-5"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056142"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.06.004"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4254"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-10-243"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm060693x"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr010194g"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052293"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1432"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188936"},{"key":"e_1_2_14_80_1","volume-title":"Silkbased biomaterials for tissue engineering topics in tissue engineering","author":"Kearns V","year":"2008"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.09.030"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.043"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoim.12499","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoim.12499","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.12499","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:38:32Z","timestamp":1696282712000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.12499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,22]]},"references-count":81,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/joim.12499"],"URL":"https:\/\/doi.org\/10.1111\/joim.12499","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,22]]}}}