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Despite recent improvement in surgical techniques, donor cornea transplantation remains plagued by risks of suboptimal optical results and visual acuity, immune rejection and eventually graft failure. Furthermore, the demand for suitable donor corneas is increasing faster than the number of donors, leaving thousands of curable patients untreated worldwide. Here, we critically review the state of the art of biomaterials for corneal regeneration. However, the lessons learned from the use of the cornea as a disease model will allow for extension of the biomaterials and techniques for regeneration of more complex organs such as the heart.<\/jats:p>","DOI":"10.1111\/joim.12502","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T09:01:59Z","timestamp":1461229319000},"page":"276-286","source":"Crossref","is-referenced-by-count":32,"title":["Regenerative approaches for the cornea"],"prefix":"10.1111","volume":"280","author":[{"given":"M.","family":"Griffith","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine Link\u00f6ping University Link\u00f6ping Sweden"},{"name":"Maisonneuve\u2010Rosemont Hospital Research Center Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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