{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:43:42Z","timestamp":1793133822326,"version":"4.5.0"},"reference-count":253,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T00:00:00Z","timestamp":1476057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["K2013\u201064X\u201014008\u201013\u20105"],"award-info":[{"award-number":["K2013\u201064X\u201014008\u201013\u20105"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["K2015\u201099X\u201022877\u201001\u20106"],"award-info":[{"award-number":["K2015\u201099X\u201022877\u201001\u20106"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","award":["Wallenberg Clinical Scholar 2015.0320"],"award-info":[{"award-number":["Wallenberg Clinical Scholar 2015.0320"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007464","name":"Torsten S\u00f6derbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007464","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["LO 2021\/2\u20101"],"award-info":[{"award-number":["LO 2021\/2\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Haemolytic uraemic syndrome (\n                    <jats:styled-content style=\"fixed-case\">HUS<\/jats:styled-content>\n                    ) is defined by the simultaneous occurrence of nonimmune haemolytic anaemia, thrombocytopenia and acute renal failure. This leads to the pathological lesion termed thrombotic microangiopathy, which mainly affects the kidney, as well as other organs.\n                    <jats:styled-content style=\"fixed-case\">HUS<\/jats:styled-content>\n                    is associated with endothelial cell injury and platelet activation, although the underlying cause may differ. Most cases of\n                    <jats:styled-content style=\"fixed-case\">HUS<\/jats:styled-content>\n                    are associated with gastrointestinal infection with Shiga toxin\u2010producing enterohaemorrhagic\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (\n                    <jats:styled-content style=\"fixed-case\">EHEC<\/jats:styled-content>\n                    ) strains. Atypical\n                    <jats:styled-content style=\"fixed-case\">HUS<\/jats:styled-content>\n                    (a\n                    <jats:styled-content style=\"fixed-case\">HUS<\/jats:styled-content>\n                    ) is associated with complement dysregulation due to mutations or autoantibodies. In this review, we will describe the causes of\n                    <jats:styled-content style=\"fixed-case\">HUS<\/jats:styled-content>\n                    . In addition, we will review the clinical, pathological, haematological and biochemical features, epidemiology and pathogenetic mechanisms as well as the biochemical, microbiological, immunological and genetic investigations leading to diagnosis. Understanding the underlying mechanisms of the different subtypes of\n                    <jats:styled-content style=\"fixed-case\">HUS<\/jats:styled-content>\n                    enables tailoring of appropriate treatment and management. To date, there is no specific treatment for\n                    <jats:styled-content style=\"fixed-case\">EHEC<\/jats:styled-content>\n                    \u2010associated\n                    <jats:styled-content style=\"fixed-case\">HUS<\/jats:styled-content>\n                    but patients benefit from supportive care, whereas patients with a\n                    <jats:styled-content style=\"fixed-case\">HUS<\/jats:styled-content>\n                    are effectively treated with anti\u2010C5 antibody to prevent recurrences, both before and after renal transplantation.\n                  <\/jats:p>","DOI":"10.1111\/joim.12546","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T04:05:49Z","timestamp":1476331549000},"page":"123-148","source":"Crossref","is-referenced-by-count":130,"title":["Haemolytic uraemic syndrome"],"prefix":"10.1111","volume":"281","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7220-7658","authenticated-orcid":false,"given":"Diana","family":"Karpman","sequence":"first","affiliation":[{"name":"Department of Pediatrics Clinical Sciences Lund Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Loos","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Clinical Sciences Lund Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Tati","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Clinical Sciences Lund Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Arvidsson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Clinical Sciences Lund Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,10]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009070706"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2010.155"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198303243081203"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91795-6"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03520170059036"},{"key":"e_1_2_14_7_1","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1128\/jcm.34.7.1622-1627.1996","article-title":"Molecular microbiological investigation of an outbreak of hemolytic\u2010uremic syndrome caused by dry fermented sausage contaminated with Shiga\u2010like toxin\u2010producing Escherichia coli","volume":"34","author":"Paton AW","year":"1996","journal-title":"J Clin Microbiol"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/322598"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.628"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268808001465"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/597399"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71144-2"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e4565"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw099"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.608"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006293422601"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1106483"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-002-1039-3"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-014-2803-x"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199011000-00013"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050353"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080643"},{"key":"e_1_2_14_23_1","first-page":"203","article-title":"Prognostic factors in typical postdiarrhea hemolytic\u2010uremic syndrome","volume":"9","author":"Robson WL","year":"1988","journal-title":"Child Nephrol Urol"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00856833"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80429-9"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2013.08.003"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0903"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft340"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq160"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-007-0540-0"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00852894"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2383-6"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2590"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-01-0007"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2006.00682.x"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268815000746"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001581"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1086\/515323"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.2807\/esm.06.10.00379-en"},{"key":"e_1_2_14_40_1","first-page":"R33","article-title":"An outbreak of Escherichia coli O157 infection linked to paddling pools","volume":"6","author":"Hildebrand JM","year":"1996","journal-title":"Commun Dis Rep CDR Rev"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1104.040739"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.1.397-400.2002"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1086\/520204"},{"key":"e_1_2_14_44_1","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1001\/jama.1993.03500070063030","article-title":"Transmission of Escherichia coli O157:H7 infection in Minnesota child day\u2010care facilities","volume":"269","author":"Belongia EA","year":"1993","journal-title":"JAMA"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.5.1773-1782.2002"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2008.525"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508103330608"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.86.8_Pt_1.1142"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010082"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.EHEC\u20100002\u20102013"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2006.3.88"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0902814"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70165-7"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.02.010"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-60"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02210310"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006080811"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-015-3076-8"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.261"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.2.636-644.1998"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr422"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(88)80093-5"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1616-9"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2006\/003178-0"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.59.11.3869-3875.1991"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000553"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01748-15"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2009.01.006"},{"key":"e_1_2_14_69_1","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1128\/iai.63.5.2070-2074.1995","article-title":"Investigation of enterohemorrhagic Escherichia coli O157:H7 adherence characteristics and invasion potential reveals a new attachment pattern shared by intestinal E. coli","volume":"63","author":"McKee ML","year":"1995","journal-title":"Infect Immun"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199901000-00022"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.2001.0447"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004619"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118168"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2006.10.005"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.10.6148-6155.2001"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90347.2008"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep13252"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1988.tb13756.x"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.EHEC\u20100009\u20102013"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.071218"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/175.3.611"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1086\/314549"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01024-10"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.3.1439-1444.1999"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13211"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182074d22"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402470"},{"key":"e_1_2_14_88_1","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1128\/iai.62.8.3337-3347.1994","article-title":"Evidence that verotoxins (Shiga\u2010like toxins) from Escherichia coli bind to P blood group antigens of human erythrocytes in vitro","volume":"62","author":"Bitzan M","year":"1994","journal-title":"Infect Immun"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.9.4355-4366.1998"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.10.3100"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20022"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1086\/322782"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006990"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/172.5.1397"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-309161"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr748"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.060003831.x"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00868253"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.moh.0000151712.53957.01"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12592"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81607-4"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7933.2004.00638.x"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH05-02-0115"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.12.8306-8316.2005"},{"key":"e_1_2_14_105_1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1182\/blood.V60.3.564.564","article-title":"Impairment of platelet aggregation in hemolytic uremic syndrome: evidence for platelet \u201cexhaustion\u201d","volume":"60","author":"Fong JS","year":"1982","journal-title":"Blood"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199903000-00008"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-08-3219"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1650291"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mn.7800198"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-939769"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011033"},{"key":"e_1_2_14_112_1","first-page":"319","article-title":"Elevated tissue factor circulating levels in children with hemolytic uremic syndrome caused by verotoxin\u2010producing E. coli","volume":"53","author":"Kamitsuji H","year":"2000","journal-title":"Clin Nephrol"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2013.03.006"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-006-0146-y"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01591-14"},{"key":"e_1_2_14_116_1","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1681\/ASN.V8121877","article-title":"Verocytotoxin inhibits mitogenesis and protein synthesis in purified human glomerular mesangial cells without affecting cell viability: evidence for two distinct mechanisms","volume":"8","author":"Van Setten PA","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012101044"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000250037.47169.55"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050337"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199806000-00008"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2000.17612"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00868714"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1159\/000188737"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1159\/000045607"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050644"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00860938"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1434-0"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70297-6"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.6.5.773-773.1999"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200212000-00019"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199810000-00010"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57313"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013050450"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws090"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1086\/591911"},{"key":"e_1_2_14_136_1","first-page":"168","article-title":"The complement system in hemolytic\u2010uremic syndrome in childhood","volume":"13","author":"Monnens L","year":"1980","journal-title":"Clin Nephrol"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1159\/000187063"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12601"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02730409"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502377"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100491"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.2.603"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.147.6.1713"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.9.1619"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02231.x"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16651"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000155"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.1998.00824.x"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005010103"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2135497100"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810739"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-133702"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100319"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603420103"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2009.04.012"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1446-9"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03552.x"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-223834"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-221549"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg363"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.030783"},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi066"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012090884"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2006.12.001"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2296-4"},{"key":"e_1_2_14_166_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-106153"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-558296"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070301"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010050451"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004050380"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-071472"},{"key":"e_1_2_14_172_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200679"},{"key":"e_1_2_14_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.373"},{"key":"e_1_2_14_174_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-205641"},{"key":"e_1_2_14_175_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013121339"},{"key":"e_1_2_14_176_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1994.1585"},{"key":"e_1_2_14_177_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-06-585430"},{"key":"e_1_2_14_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(94)00157-V"},{"key":"e_1_2_14_179_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939280"},{"key":"e_1_2_14_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2006.10.005"},{"key":"e_1_2_14_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.472"},{"key":"e_1_2_14_182_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.09.040191.002243"},{"key":"e_1_2_14_183_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-007252"},{"key":"e_1_2_14_184_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1352.032"},{"key":"e_1_2_14_185_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-383281"},{"key":"e_1_2_14_186_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-197640"},{"key":"e_1_2_14_187_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013070796"},{"key":"e_1_2_14_188_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21256"},{"key":"e_1_2_14_189_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.18.6425"},{"key":"e_1_2_14_190_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-489245"},{"key":"e_1_2_14_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2011.02.010"},{"key":"e_1_2_14_192_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31829ee872"},{"key":"e_1_2_14_193_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-012-1854-x"},{"key":"e_1_2_14_194_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.063479-0"},{"key":"e_1_2_14_195_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw029"},{"key":"e_1_2_14_196_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149307"},{"key":"e_1_2_14_197_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft198"},{"key":"e_1_2_14_198_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013080886"},{"key":"e_1_2_14_199_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01640214"},{"key":"e_1_2_14_200_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0986-8"},{"key":"e_1_2_14_201_1","doi-asserted-by":"publisher","DOI":"10.1179\/102453308X343518"},{"key":"e_1_2_14_202_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-522128"},{"key":"e_1_2_14_203_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs456"},{"key":"e_1_2_14_204_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2011.152"},{"key":"e_1_2_14_205_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2236"},{"key":"e_1_2_14_206_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015\u20102153"},{"key":"e_1_2_14_207_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis299"},{"key":"e_1_2_14_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2015.08.006"},{"key":"e_1_2_14_209_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.264"},{"key":"e_1_2_14_210_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis531"},{"key":"e_1_2_14_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80071-4"},{"key":"e_1_2_14_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01251-9"},{"key":"e_1_2_14_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61145-8"},{"key":"e_1_2_14_214_1","first-page":"585","article-title":"Plasma exchange therapy for the treatment of Escherichia coli O\u2010157 associated hemolytic uremic syndrome","volume":"10","author":"Nakatani T","year":"2002","journal-title":"Int J Mol Med"},{"key":"e_1_2_14_215_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs394"},{"key":"e_1_2_14_216_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1100859"},{"key":"e_1_2_14_217_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv004"},{"key":"e_1_2_14_218_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12297"},{"key":"e_1_2_14_219_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0964-1"},{"key":"e_1_2_14_220_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1262890"},{"key":"e_1_2_14_221_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2558-9"},{"key":"e_1_2_14_222_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-014-2948-7"},{"key":"e_1_2_14_223_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-014-0416-x"},{"key":"e_1_2_14_224_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.12.034"},{"key":"e_1_2_14_225_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208981"},{"key":"e_1_2_14_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2015.11.026"},{"key":"e_1_2_14_227_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04252.x"},{"key":"e_1_2_14_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2015.05.018"},{"key":"e_1_2_14_229_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21208"},{"key":"e_1_2_14_230_1","volume-title":"GeneReviews(R)","author":"Carrillo\u2010Carrasco N","year":"1993"},{"key":"e_1_2_14_231_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01471-13"},{"key":"e_1_2_14_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2012.04.001"},{"key":"e_1_2_14_233_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800052158"},{"key":"e_1_2_14_234_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-002-0966-3"},{"key":"e_1_2_14_235_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP71563"},{"key":"e_1_2_14_236_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.057174-0"},{"key":"e_1_2_14_237_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.03.039"},{"key":"e_1_2_14_238_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4142"},{"key":"e_1_2_14_239_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-014-0482-z"},{"key":"e_1_2_14_240_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(89)80155-6"},{"key":"e_1_2_14_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2016.04.009"},{"key":"e_1_2_14_242_1","first-page":"54","article-title":"De novo hemolytic uremic syndrome in renal transplant recipients immunosuppressed with cyclosporine","volume":"98","author":"Van Buren D","year":"1985","journal-title":"Surgery"},{"key":"e_1_2_14_243_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.07.012"},{"key":"e_1_2_14_244_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12582"},{"key":"e_1_2_14_245_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-0968.2003.00127.x"},{"key":"e_1_2_14_246_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2005.00478.x"},{"key":"e_1_2_14_247_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-016-3355-z"},{"key":"e_1_2_14_248_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.31.479"},{"key":"e_1_2_14_249_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-007-0604-1"},{"key":"e_1_2_14_250_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670000389"},{"key":"e_1_2_14_251_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.5.1028"},{"key":"e_1_2_14_252_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-001-0792-z"},{"key":"e_1_2_14_253_1","doi-asserted-by":"publisher","DOI":"10.1086\/314019"},{"key":"e_1_2_14_254_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-18603-0_2"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoim.12546","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoim.12546","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.12546","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:04:48Z","timestamp":1695542688000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.12546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,10]]},"references-count":253,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/joim.12546"],"URL":"https:\/\/doi.org\/10.1111\/joim.12546","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,10]]}}}