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However, clinical studies have to date not clarified whether these adverse cardiometabolic effects are induced directly by dietary sugars, or whether they are secondary to weight gain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the effects of fructose (75 g day<jats:sup>\u22121<\/jats:sup>), served with their habitual diet over 12 weeks, on liver fat content and other cardiometabolic risk factors in a large cohort (<jats:italic>n<\/jats:italic> = 71) of abdominally obese men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed changes in body composition, dietary intake, an extensive panel of cardiometabolic risk markers, hepatic <jats:italic>de novo<\/jats:italic> lipogenesis (<jats:styled-content style=\"fixed-case\">DNL<\/jats:styled-content>), liver fat content and postprandial lipid responses after a standardized oral fat tolerance test (<jats:styled-content style=\"fixed-case\">OFTT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fructose consumption had modest adverse effects on cardiometabolic risk factors. However, fructose consumption significantly increased liver fat content and hepatic <jats:styled-content style=\"fixed-case\">DNL<\/jats:styled-content> and decreased \u03b2\u2010hydroxybutyrate (a measure of \u03b2\u2010oxidation). The individual changes in liver fat were highly variable in subjects matched for the same level of weight change. The increase in liver fat content was significantly more pronounced than the weight gain. The increase in <jats:styled-content style=\"fixed-case\">DNL<\/jats:styled-content> correlated positively with triglyceride area under the curve responses after an <jats:styled-content style=\"fixed-case\">OFTT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data demonstrated adverse effects of moderate fructose consumption for 12 weeks on multiple cardiometabolic risk factors in particular on liver fat content despite only relative low increases in weight and waist circumference. Our study also indicates that there are remarkable individual differences in susceptibility to visceral adiposity\/liver fat after real\u2010world daily consumption of fructose\u2010sweetened beverages over 12 weeks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12632","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T09:42:59Z","timestamp":1495791779000},"page":"187-201","source":"Crossref","is-referenced-by-count":105,"title":["Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity"],"prefix":"10.1111","volume":"282","author":[{"given":"M.\u2010R.","family":"Taskinen","sequence":"first","affiliation":[{"name":"Research Programs Unit Diabetes and Obesity University of Helsinki and Heart and Lung Center Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"S\u00f6derlund","sequence":"additional","affiliation":[{"name":"Research Programs Unit Diabetes and Obesity University of Helsinki and Heart and Lung Center Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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