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This has provided important information about recurrent genetic events and identified key pathways deregulated in each lymphoma subtype. In parallel, there has been intense search and development of novel types of targeted therapy that \u2018hit\u2019 central mechanisms in lymphoma pathobiology, such as BTK, PI3K or BCL2 inhibitors. In this review, we will outline the current view of the genetic landscape of selected entities: follicular lymphoma, diffuse large B\u2010cell lymphoma, mantle cell lymphoma, chronic lymphocytic leukaemia and marginal zone lymphoma. We will detail recurrent alterations affecting important signalling pathways, that is the B\u2010cell receptor\/NF\u2010\u03baB pathway, NOTCH signalling, JAK\u2010STAT signalling, p53\/DNA damage response, apoptosis and cell cycle regulation, as well as other perhaps unexpected cellular processes, such as immune regulation, cell migration, epigenetic regulation and RNA processing. Whilst many of these pathways\/processes are commonly altered in different lymphoid tumors, albeit at varying frequencies, others are preferentially targeted in selected B\u2010cell malignancies. Some of these genetic lesions are either involved in disease ontogeny or linked to the evolution of each disease and\/or specific clinicobiological features, and some of them have been demonstrated to have prognostic and even predictive impact. Future work is especially needed to understand the therapy\u2010resistant disease, particularly in patients treated with targeted therapy, and to identify novel targets and therapeutic strategies in order to realize true precision medicine in this clinically heterogeneous patient group.<\/jats:p>","DOI":"10.1111\/joim.12633","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T06:29:01Z","timestamp":1497940141000},"page":"371-394","source":"Crossref","is-referenced-by-count":61,"title":["Genetic landscape and deregulated pathways in B\u2010cell lymphoid malignancies"],"prefix":"10.1111","volume":"282","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0211-8788","authenticated-orcid":false,"given":"R.","family":"Rosenquist","sequence":"first","affiliation":[{"name":"Department of Immunology Genetics and Pathology Science for Life Laboratory Uppsala University Uppsala Sweden"},{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet 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