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Participants were followed up by linking them to registry data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the Discovery cohort (653 deaths; 216 <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\u2010related, 231 cancer\u2010related), fully adjusted Cox proportional hazard regression models showed that increased plasma hepatocyte growth factor (<jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content>) and placental growth factor (Pl<jats:styled-content style=\"fixed-case\">GF<\/jats:styled-content>) were associated with higher risk of 10\u2010year mortality (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 1.29 [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), 1.18\u20131.41] and <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 1.23 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.14\u20131.32], respectively). In the Replication cohort (259 deaths; 83 <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\u2010related, 90 cancer\u2010related), baseline <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content> levels also predicted all\u2010cause mortality (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 1.2 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.08\u20131.32]; Pl<jats:styled-content style=\"fixed-case\">GF<\/jats:styled-content> data not available). By including <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content> levels in a <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> mortality model, 9% of all <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> deaths were correctly reclassified in the Discovery cohort (categorical net reclassification improvement [<jats:styled-content style=\"fixed-case\">NRI<\/jats:styled-content>] for events, <jats:italic>P<\/jats:italic>\u00a0=\u00a04.0\u00a0\u00d7\u00a010<jats:sup>\u22124<\/jats:sup>). Moreover, adding <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content> to all\u2010cause and <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> mortality models resulted in an overall clinical <jats:styled-content style=\"fixed-case\">NRI<\/jats:styled-content> of 0.10\u20130.18 in the Discovery cohort and meta\u2010analyses (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 for all tests).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Blood levels of <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content> and Pl<jats:styled-content style=\"fixed-case\">GF<\/jats:styled-content> may serve as new biomarkers for predicting increased risk of death in the general population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12648","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T14:57:45Z","timestamp":1499353065000},"page":"340-352","source":"Crossref","is-referenced-by-count":29,"title":["Plasma levels of hepatocyte growth factor and placental growth factor predict mortality in a general population: a prospective cohort study"],"prefix":"10.1111","volume":"282","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3505-9734","authenticated-orcid":false,"given":"K.","family":"Santalahti","sequence":"first","affiliation":[{"name":"MediCity Research Laboratory University of Turku Turku Finland"},{"name":"Department of Medical Microbiology and Immunology University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Havulinna","sequence":"additional","affiliation":[{"name":"Department of Public Health Solutions National Institute for Health and Welfare Helsinki 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