{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:36:27Z","timestamp":1782297387897,"version":"3.54.5"},"reference-count":80,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    People with chronic kidney disease (\n                    <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n                    ) are at risk of severe outcomes, such as end\u2010stage renal disease or cardiovascular disease, and\n                    <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n                    is a globally increasing health burden with a high personal and economic cost. Despite major progresses in prevention and therapeutics in last decades, research is still needed to reverse this epidemic trend. The regulation of water balance and the state of activation of the vasopressin system have emerged as factors tightly associated with kidney health, in the general population but also in specific conditions; among them, various stages of\n                    <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n                    , diabetes and autosomal dominant polycystic kidney disease (\n                    <jats:styled-content style=\"fixed-case\">ADPKD<\/jats:styled-content>\n                    ). Basic science findings and also epidemiological evidence have justified important efforts towards interventional studies supporting causality, and opening therapeutic avenues. On the basis of recent clinical data, the blockade of V2 vasopressin receptors using tolvaptan in patients with rapidly progressing\n                    <jats:styled-content style=\"fixed-case\">ADPKD<\/jats:styled-content>\n                    has been granted in several countries, and a long\u2010term randomized trial evaluating the effect of an increase in water intake in patients with\n                    <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>\n                    is on\u2010going.\n                  <\/jats:p>","DOI":"10.1111\/joim.12654","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T03:10:59Z","timestamp":1505358659000},"page":"310-321","source":"Crossref","is-referenced-by-count":17,"title":["The vasopressin system: new insights for patients with kidney diseases"],"prefix":"10.1111","volume":"282","author":[{"given":"W. 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