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Examples include the rare skin tumour dermatofibrosarcoma protuberance, which is driven by autocrine <jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content> stimulation due to translocation of a <jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content> gene, and certain gastrointestinal stromal tumours and leukaemias, which are driven by constitute activation of <jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content> receptors due to point mutations and formation of fusion proteins of\u00a0the receptors, respectively. Moreover, <jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content> stimulates cells in tumour stroma and promotes angiogenesis as well as the development of cancer\u2010associated fibroblasts, both of which promote tumour progression. 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