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With new promising therapies, survival may improve for severe <jats:styled-content style=\"fixed-case\">aGVHD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We wanted to analyze the long\u2010term outcome in patients who survive severe <jats:styled-content style=\"fixed-case\">aGVHD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a landmark analysis of 23 567 patients with acute Leukaemia who survived for more than 6 months after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, 2002\u20132014. Patients alive after severe <jats:styled-content style=\"fixed-case\">aGVHD<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 1738) were compared to controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with severe <jats:styled-content style=\"fixed-case\">aGVHD<\/jats:styled-content> had higher non\u2010relapse mortality (<jats:styled-content style=\"fixed-case\">NRM<\/jats:styled-content>) and higher rate of extensive chronic <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">cGVHD<\/jats:styled-content>) than the controls (<jats:italic>P<\/jats:italic> &lt; 10<jats:sup>\u22125<\/jats:sup>). The probability of relapse was significantly lower in the severe <jats:styled-content style=\"fixed-case\">aGVHD<\/jats:styled-content> group, but Leukaemia\u2010free survival (<jats:styled-content style=\"fixed-case\">LFS<\/jats:styled-content>) and overall survival were significantly lower than for the controls (<jats:italic>P<\/jats:italic> &lt; 10<jats:sup>\u22125<\/jats:sup>). Five\u2010year <jats:styled-content style=\"fixed-case\">LFS<\/jats:styled-content> in patients with severe <jats:styled-content style=\"fixed-case\">aGVHD<\/jats:styled-content> was 49%, as opposed to 61% in controls with no or mild <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> and 59% in patients with moderate GVHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> patients who survive severe <jats:styled-content style=\"fixed-case\">aGVHD<\/jats:styled-content> have higher risk of developing extensive <jats:styled-content style=\"fixed-case\">cGVHD<\/jats:styled-content>, a higher <jats:styled-content style=\"fixed-case\">NRM<\/jats:styled-content>, a lower relapse probability, and lower <jats:styled-content style=\"fixed-case\">LFS<\/jats:styled-content> than other <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> patients. This study is a platform for outcome analysis in patients treated with novel therapies for acute GVHD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12695","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T09:02:54Z","timestamp":1507885374000},"page":"166-177","source":"Crossref","is-referenced-by-count":12,"title":["What is the outcome in patients with acute leukaemia who survive severe acute graft\u2010versus\u2010host disease?"],"prefix":"10.1111","volume":"283","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6092-1536","authenticated-orcid":false,"given":"O.","family":"Ringd\u00e9n","sequence":"first","affiliation":[{"name":"Division of Therapeutic Immunology Karolinska Institutet Karolinska University Hospital Huddinge Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Labopin","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint Antoine Paris 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