{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:27:58Z","timestamp":1780471678756,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T00:00:00Z","timestamp":1510617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Subclinical chronic inflammation could be the driving force behind the recently revealed association between abnormal nailfold capillaries as well as autoantibodies and long\u2010term mortality in patients with incipient Raynaud's phenomenon. Whether laboratory markers that reflect a chronic inflammatory process are directly related to mortality in Raynaud's phenomenon is not known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 2958 patients with incipient Raynaud's phenomenon without previously known connective tissue disease (<jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content>) were enrolled. At their initial presentation, laboratory tests for C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>), leucocytes, fibrinogen and the haemoglobin concentration were obtained. In addition, nailfold capillaries and antinuclear antibodies (<jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content>) were assessed. Patients\u2019 mortality was recorded through a median follow\u2010up period of 9.3 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>, fibrinogen and haemoglobin concentration were associated with long\u2010term mortality in an individual analysis of patients with incipient Raynaud\u2032s phenomenon. In a multivariable model including patients\u2019 age, nailfold capillaries and <jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content>, a low haemoglobin concentration remained independently related to future mortality. Amongst potential predictors for mortality in patients with Raynaud's phenomenon, a low haemoglobin concentration was most strongly related to patients\u2019 mortality risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In Raynaud's phenomenon, laboratory markers that can be attributed to a chronic inflammatory state independently yield prognostic information in addition to the presence of abnormal nailfold capillaries and <jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content>. Amongst all prognostic markers, the haemoglobin concentration is most strongly related to patients\u2019 mortality in Raynaud's phenomenon.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12705","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T11:58:36Z","timestamp":1508932716000},"page":"293-302","source":"Crossref","is-referenced-by-count":4,"title":["Chronic inflammation predicts long\u2010term mortality in patients with Raynaud's phenomenon"],"prefix":"10.1111","volume":"283","author":[{"given":"M.","family":"Mueller","sequence":"first","affiliation":[{"name":"Division of Angiology Department of Medicine II Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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