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The molecular mechanisms for\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    8+ T\u2010cell expansion remain poorly characterized. In this article, we review the literature addressing features of\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    8+ T\u2010cell immune pathology and present an integrated view on the mechanisms leading to abnormal\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    8+ T\u2010cell expansion during\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    \u20101 infection. The expression of molecules important for directing the homing of\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    8+ T cells between the circulation and lymphoid tissues, in particular\n                    <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>\n                    5 and\n                    <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>\n                    3, is increased in\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    8+ T cells in circulation and in inflamed tissues during\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    \u20101 infection; these disturbances in the homing capacity of\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    8+ T cells have been linked to increased\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    8+ T\u2010cell proliferation. The production of\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201015, a cytokine responsible for physiological proliferation of\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    8+ T cells, is increased in lymphoid tissues during\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    \u20101 infection as result of microbial translocation and severe inflammation.\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201015, and additional inflammatory cytokines, may lead to deregulated proliferation of\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    8+ T cells and explain the accumulation of\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    8+ T cells in circulation. The decreased capacity of\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    8+ T cells to localize to gut\u2010associated lymphoid tissue also contributes to the accumulation of these cells in blood. Control of inflammation, through\n                    <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>\n                    administration during primary\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    \u20101 infection or therapies aimed at controlling inflammation during\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    \u20101 infection, is pivotal to prevent abnormal expansion of\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    8+ T cells during\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    \u20101 infection.\n                  <\/jats:p>","DOI":"10.1111\/joim.12722","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T19:26:22Z","timestamp":1515525982000},"page":"257-267","source":"Crossref","is-referenced-by-count":21,"title":["Mechanisms regulating expansion of\n                    <scp>CD<\/scp>\n                    8+ T cells during\n                    <scp>HIV<\/scp>\n                    \u20101 infection"],"prefix":"10.1111","volume":"283","author":[{"given":"A.","family":"Nasi","sequence":"first","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1385-8343","authenticated-orcid":false,"given":"F.","family":"Chiodi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/4772"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302027"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu669"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ809"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000223028.55080.9d"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01183-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-012-9400-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085798"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004078"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05126.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/87720"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.10.5864"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.4.1528"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5408.1745"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00942.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117892"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-055764"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5292.1543"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.8.1295"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.1.249"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020020"},{"key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.4049\/jimmunol.148.6.1620","article-title":"Extrathymic T cell maturation. 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