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We added meta\u2010analyses of LCT<\/jats:styled-content>\u201013910<\/jats:italic> and fractures and BMD<\/jats:styled-content> from five published Northern European population studies.<\/jats:p><\/jats:sec>Results<\/jats:title>In the Danish studies, the adjusted hazard ratio (HR<\/jats:styled-content>) for hip fracture per one glass per week higher milk intake was 1.00 (95% CI<\/jats:styled-content>: 0.99\u20131.01). The per T<\/jats:italic>\u2010allele milk intake was 0.58 (0.49\u20130.68) glasses per week, but HR<\/jats:styled-content> was 1.01 (0.94\u20131.09) for hip fracture. In meta\u2010analyses of Danish studies with published Northern European population studies, the random effects odds ratio for any fracture was 0.86 (0.61\u20131.21; I<\/jats:italic>2<\/jats:sup> = 73%) for TT<\/jats:styled-content> vs<\/jats:italic>. CC<\/jats:styled-content><\/jats:italic> and 0.90 (0.68\u20131.21; I<\/jats:italic>2<\/jats:sup> = 63%) for TC<\/jats:styled-content> vs<\/jats:italic>. CC<\/jats:styled-content><\/jats:italic>. The standardized mean difference in femoral neck BMD<\/jats:styled-content> was 0.10 (0.02\u20130.18; I<\/jats:italic>2<\/jats:sup> = 0%) g cm\u22122<\/jats:sup> for TT<\/jats:styled-content> vs<\/jats:italic>. CC<\/jats:styled-content><\/jats:italic> and 0.06 (\u22120.04 to 0.17; I<\/jats:italic>2<\/jats:sup> = 17%) g cm\u22122<\/jats:sup> for TC<\/jats:styled-content> vs<\/jats:italic>. CC<\/jats:styled-content><\/jats:italic>. There were no differences in lumbar spine or total hip BMD<\/jats:styled-content> comparing TT<\/jats:styled-content><\/jats:italic> or TC<\/jats:styled-content><\/jats:italic> with CC<\/jats:styled-content><\/jats:italic>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Genetically lifelong lactase persistence with high milk intake was not associated with hip fracture in Danish population\u2010based cohorts. A meta\u2010analysis combining Danish studies with published Northern European population studies also showed that lactase persistence was not associated with fracture risk. Genetic lactase persistence was associated with a higher femoral neck BMD<\/jats:styled-content>, but not lumbar spine or total hip BMD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12753","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T12:20:24Z","timestamp":1521116424000},"page":"254-269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Lactase persistence, milk intake, hip fracture and bone mineral density: a study of 97 811 Danish individuals and a meta\u2010analysis"],"prefix":"10.1111","volume":"284","author":[{"given":"H. K. M.","family":"Bergholdt","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital Naestved Slagelse Ringsted Naestved Denmark"},{"name":"The Danish General Suburban Population Study Copenhagen University Hospital Naestved Slagelse Ringsted Naestved Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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