{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T18:44:29Z","timestamp":1746816269781,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2011\u201030405","2007\u20107469"],"award-info":[{"award-number":["2011\u201030405","2007\u20107469"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["20090710"],"award-info":[{"award-number":["20090710"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["2009B026"],"award-info":[{"award-number":["2009B026"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Both hepatitis B and C viruses were transmitted through blood transfusion before implementation of donor screening. The existence of additional, yet unknown transfusion transmittable agents causing liver disease could have important public health implications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Analyses were based on the Scandinavian Donations and Transfusions (<jats:styled-content style=\"fixed-case\">SCANDAT<\/jats:styled-content>2) database. Cox regression models were used to estimate the hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) of developing chronic liver disease in recipients of blood from donors who later developed any chronic liver disease compared to recipients who received blood transfusion from healthy donors. We also studied whether the risk of liver disease was increased in patients who received units from \u2018high\u2010risk\u2019 donors, defined as donors who had a higher than expected occurrence of liver disease amongst their previous recipients. All analyses were stratified before and after 1992 to account for the effect of screening for hepatitis C virus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1 482 922 transfused patients were included in the analyses. Analyses showed evidence of transfusion transmission of liver diseases before, but not after the implementation of hepatitis C virus screening in 1992, with <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>s for any liver disease of 1.38 [95% confidence interval (CI), 1.30\u20131.46] and 0.99 (95% CI, 0.91\u20131.07), before and after 1992, respectively. Similarly, blood components from \u2018high\u2010risk\u2019 donors conferred increased risks before, but not after 1992.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data provide no evidence for transfusion transmission of agents causing liver disease after the implementation of screening for hepatitis B and C, and suggest that if such transmission does occur, it is rare.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12762","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T21:49:32Z","timestamp":1523051372000},"page":"92-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Searching for unknown transfusion\u2010transmitted hepatitis viruses: a binational cohort study of 1.5 million transfused patients"],"prefix":"10.1111","volume":"284","author":[{"given":"G.","family":"Edgren","sequence":"first","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"},{"name":"Department of Cardiology S\u00f6dersjukhuset Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Hjalgrim","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark"},{"name":"Department of Hematology Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Rostgaard","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Monitoring and Evaluation Public Health Agency of Sweden Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Titlestad","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Erikstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wikman","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Transfusion Medicine Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Laboratory Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Norda","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7024-8787","authenticated-orcid":false,"given":"A.","family":"Majeed","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"},{"name":"Department of Gastroenterology The Alfred Health Melbourne Vic. Australia"},{"name":"Central Clinical School Monash University Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the NHLBI Recipient Epidemiology and Donor Evaluation Study\u2010III (REDS\u2010III)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1943.02840170016005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-101-6-733"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-104-4-488"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2523562"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1769-9"},{"key":"e_1_2_7_7_1","first-page":"1836","article-title":"Cryptogenic liver disease in the United States: further evidence for non\u2010A, non\u2010B, and non\u2010C hepatitis","volume":"89","author":"Kodali VP","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290347"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2006.00827.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12986"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-009-9350-y"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-450"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15-2421"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60779-X"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12342"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709011223"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70057-X"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1994.tb04539.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841868909092300"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61034-5"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.9.786"},{"key":"e_1_2_7_22_1","first-page":"535","article-title":"The Danish Cancer Registry \u2013 history, content, quality and use","volume":"44","author":"Storm HH","year":"1997","journal-title":"Dan Med Bull"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39299154734.x"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoim.12762","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.12762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:26:07Z","timestamp":1695515167000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.12762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,25]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/joim.12762"],"URL":"https:\/\/doi.org\/10.1111\/joim.12762","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"type":"print","value":"0954-6820"},{"type":"electronic","value":"1365-2796"}],"subject":[],"published":{"date-parts":[[2018,4,25]]},"assertion":[{"value":"2018-04-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}