{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:30:37Z","timestamp":1792042237116,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T00:00:00Z","timestamp":1526947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/objectives<\/jats:title><jats:p>The Oslo diet and antismoking study showed that counselling for a healthy lifestyle reduced lifelong coronary mortality in high\u2010risk men. We explored whether the same counselling reduced also cancer risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study randomly allocated males at high coronary risk to either a 5\u2010year intervention for lifestyle changes (cholesterol\u2010lowering dietary changes, weight loss and stopping smoking) or a control group (1 : 1) in 1972\/73. We explored the incidence and mortality of all cancers and cancer forms related to smoking, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> or diet up to 43 years after randomization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 595 men in the intervention and 621 in the control group were included. At inclusion median age was 45 years, 588 (48.4%) subjects were overweight (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> &gt; 25 kg m<jats:sup>\u22122<\/jats:sup>) and 925 (76.1%) current smokers. The intervention did not reduce the risk of cancer after 43 years (adjusted hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) 0.96, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 0.80\u20131.15). In the first 25 years of follow\u2010up, among the 1088 (89.5%) men who were overweight\/obese and\/or smokers, the intervention reduced the incidence of those cancer forms related to smoking, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> or diet (including carcinoma of the respiratory, digestive and urinary tracts; adjusted <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.69; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.49\u20130.99). The intervention had no significant effect on incidence beyond 25 years, or on mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The 5\u2010year counselling for a healthy lifestyle did not reduce the overall cancer risk in the very long term. However, in the first 25 years, the counselling reduced the risk of relevant cancer types in overweight\/obese subjects and smokers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12765","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T05:01:26Z","timestamp":1527051686000},"page":"282-291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exploring the effect of a lifestyle intervention on cancer risk: 43\u2010year follow\u2010up of the randomized Oslo diet and antismoking study"],"prefix":"10.1111","volume":"284","author":[{"given":"E.","family":"Botteri","sequence":"first","affiliation":[{"name":"Department of Bowel cancer screening Cancer Registry of Norway Oslo Norway"},{"name":"Norwegian National Advisory Unit for Women's Health Women's Clinic Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"de Lange","sequence":"additional","affiliation":[{"name":"Department of Bowel cancer screening Cancer Registry of Norway Oslo Norway"},{"name":"Unit for Research, Innovation and Education Oslo University Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tonstad","sequence":"additional","affiliation":[{"name":"Department of Preventive Cardiology Oslo University Hospital Oslo Norway"},{"name":"School of Public Health Loma Linda University Loma Linda CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9025-4455","authenticated-orcid":false,"given":"P.","family":"Berstad","sequence":"additional","affiliation":[{"name":"Department of Bowel cancer screening Cancer Registry of Norway Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,22]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Norwegian Institute of Public Health.The disease burden in Norway 1990\u20102013. 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