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Apart from nonmodifiable factors such as ageing, family history and gender, both sedentary lifestyle and unhealthy dietary habits are considered as major risk factors. The disorders are interrelated suggesting common pathological pathways. Mechanistically, oxidative stress and compromised function of the nitric oxide synthase (\n                    <jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>\n                    ) system leading to endothelial dysfunction and reduction in nitric oxide (\n                    <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                    ) bioavailability have been widely implicated and associated with development and progression of disease. New strategies that correct this redox imbalance and increase\n                    <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                    bioactivity may have major clinical implications. The inorganic anions, nitrate and nitrite, are endogenously formed by oxidization of\n                    <jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>\n                    \u2010derived\n                    <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                    , but there are also high amounts of nitrate in our daily diet. In this regard, accumulated evidence over the past two decades demonstrates that these anions can be recycled back to\n                    <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                    and other bioactive nitrogen oxides, thus offering an attractive alternative strategy for therapeutic exploitation. In this review, we describe how dietary stimulation of the nitrate\u2013nitrite\u2013\n                    <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                    pathway affects cardiovascular and renal functions in health and disease via modulation of oxidative stress and\n                    <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\n                    bioavailability. Clinical studies addressing potential effects on the renal system are still limited, but blood pressure\u2010lowering effects of nitrate supplementation have been demonstrated in healthy and hypertensive subjects as well as in patients with chronic kidney disease. However, larger clinical studies are warranted to reveal whether chronic nitrate treatment can slow\u2010down the progression of cardiorenal disease and associated complications.\n                  <\/jats:p>","DOI":"10.1111\/joim.12818","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T03:43:09Z","timestamp":1532403789000},"page":"2-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Therapeutic value of stimulating the nitrate\u2010nitrite\u2010nitric oxide pathway to attenuate oxidative stress and restore nitric oxide bioavailability in cardiorenal disease"],"prefix":"10.1111","volume":"285","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9923-8729","authenticated-orcid":false,"given":"M.","family":"Carlstrom","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9137-8145","authenticated-orcid":false,"given":"M. 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