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The supply of animal\u2010derived lung surfactants is limited and only a part of the preterm babies is treated. Thus, there is a need to develop well\u2010defined synthetic replicas based on key components of natural surfactant. A synthetic product that equals natural\u2010derived surfactants would enable cost\u2010efficient production and could also facilitate the development of the treatments of other lung diseases than neonatal <jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content>. Recently the first synthetic surfactant that contains analogues of the two hydrophobic surfactant proteins B (<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010B) and <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010C entered clinical trials for the treatment of neonatal <jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content>. The development of functional synthetic analogues of <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010B and <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010C, however, is considerably more challenging than anticipated 30\u00a0years ago when the first structural information of the native proteins became available. For <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010B, a complex three\u2010dimensional dimeric structure stabilized by several disulphides has necessitated the design of miniaturized analogues. The main challenge for <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010C has been the pronounced amyloid aggregation propensity of its transmembrane region. The development of a functional non\u2010aggregating <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\u2010C analogue that can be produced synthetically was achieved by designing the amyloidogenic native sequence so that it spontaneously forms a stable transmembrane \u03b1\u2010helix.<\/jats:p>","DOI":"10.1111\/joim.12845","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T20:56:17Z","timestamp":1540414577000},"page":"165-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Synthetic surfactants with <scp>SP<\/scp>\u2010B and <scp>SP<\/scp>\u2010C analogues to enable worldwide treatment of neonatal respiratory distress syndrome and other lung diseases"],"prefix":"10.1111","volume":"285","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8719-4703","authenticated-orcid":false,"given":"J.","family":"Johansson","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society Section\u00a0for Neurogeriatrics Karolinska Institutet Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Curstedt","sequence":"additional","affiliation":[{"name":"Laboratory for Surfactant Research Department of Molecular Medicine and Surgery Karolinska Institutet at Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1152\/ajplegacy.1972.223.3.715","article-title":"Surface active materials from dog lung. 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