{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T21:26:14Z","timestamp":1775510774536,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000327","name":"Heart Research UK","doi-asserted-by":"publisher","award":["RG 2579\/09\/10"],"award-info":[{"award-number":["RG 2579\/09\/10"]}],"id":[{"id":"10.13039\/501100000327","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>There are limited data on the role of human monocyte subsets in <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\u2010elevation myocardial infarction (<jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>). The study aimed to establish the relationship between monocyte subsets, their phagocytic and nuclear factor \u03baB (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u03baB) activity and outcomes in <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Monocyte subsets and their phagocytic activity and intracellular levels of inhibitory \u03baB kinase \u03b2 (<jats:styled-content style=\"fixed-case\">IKK<\/jats:styled-content>\u03b2, marker of <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u03baB activity) were measured by flow cytometry in 245 patients with <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>, median follow\u2010up of 46\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mon2 (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>14++<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>16+<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>2+) counts were independently predictive of major adverse cardiovascular events (MACE) [4th quartile <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 3.42 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.43\u20138.16), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006 and 3rd quartile <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2.88 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.19\u20137.00), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02 vs. 1st quartile]. Mon2 subset was the only subset associated with higher occurrence of heart failure (4th quartile vs. 1st quartile, sevenfold, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001 on univariate analysis; fivefold, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04 on multivariable analysis). On receiver operating characteristic, analysis including of Mon2 improved prognostic value of troponin T and creatine kinase for <jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content> and heart failure (<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>). Higher intracellular Mon2 <jats:styled-content style=\"fixed-case\">IKK<\/jats:styled-content>\u03b2 levels were associated with 10\u2010fold lower occurrence of <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> on multivariable analysis (4th vs. 1st quartiles, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). Abnormal Mon1 and Mon2 phagocytic capacities were related to <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> development, but the association was dependent on the infarct size and other prognosticators. High Mon2 levels were associated with lower ejection fraction after <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content> onset (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) and at 6\u2010month follow\u2010up (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Abnormal Mon2 characteristics have a unique association with poor outcome in patients with <jats:styled-content style=\"fixed-case\">STEMI<\/jats:styled-content>. The relation of Mon2 with occurrence of <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> is strongly and independently related to their functional status, which may have potential therapeutic implications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12847","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T14:19:15Z","timestamp":1547561955000},"page":"301-316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Mon2 predicts poor outcome in <scp>ST<\/scp>\u2010elevation myocardial infarction"],"prefix":"10.1111","volume":"285","author":[{"given":"E.","family":"Shantsila","sequence":"first","affiliation":[{"name":"University of Birmingham Centre for Cardiovascular Sciences City Hospital Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ghattas","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences Aston University Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. R.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Surrey Guildford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science University of Birmingham Liverpool UK"},{"name":"Liverpool Centre for Cardiovascular Science University of Liverpool and Liverpool Heart &amp; Chest Hospital Liverpool UK"},{"name":"Aalborg Thrombosis Research Unit Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.180513"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.11.015"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.46.1.455"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.303567"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.11.019"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070885"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1126\/science.1175202","article-title":"Identification of splenic reservoir monocytes and their deployment to inflammatory sites","volume":"325","author":"Swirski FK","year":"2009","journal-title":"Science (New York, NY)"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-02-0091"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1112"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.021"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04244.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn416"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04603.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03625.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euje.2005.12.014"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4509"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.14-174"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003466"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.019"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570161116666180601083225"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.08.027"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003597"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoim.12847","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.12847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T02:42:01Z","timestamp":1694659321000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.12847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,15]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/joim.12847"],"URL":"https:\/\/doi.org\/10.1111\/joim.12847","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,15]]},"assertion":[{"value":"2019-01-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}