{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:11:53Z","timestamp":1792671113653,"version":"4.5.0"},"reference-count":105,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T00:00:00Z","timestamp":1542931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Postural orthostatic tachycardia syndrome (\n                    <jats:styled-content style=\"fixed-case\">POTS<\/jats:styled-content>\n                    ) is a variant of cardiovascular autonomic disorder characterized by an excessive heart rate increase on standing and orthostatic intolerance.\n                    <jats:styled-content style=\"fixed-case\">POTS<\/jats:styled-content>\n                    affects\u00a0younger individuals 15\u201345\u00a0years old with a distinct female predominance (\u224880%). The prevalence ranges between 0.2% and 1.0% in developed countries. The onset of\n                    <jats:styled-content style=\"fixed-case\">POTS<\/jats:styled-content>\n                    is typically precipitated by immunological stressors such as viral infection, vaccination, trauma, pregnancy, surgery or psychosocial stress. The most common complaints are dizziness, weakness, rapid heartbeat and palpitation on standing. Moreover, patients often report physical deconditioning and reduced exercise capacity as well as headache, \u2018brain fog\u2019, dyspnoea, gastrointestinal disorders and musculoskeletal pain. The aetiology of\n                    <jats:styled-content style=\"fixed-case\">POTS<\/jats:styled-content>\n                    is largely unknown and three main hypotheses include an autoimmune disorder, abnormally increased sympathetic activity and catecholamine excess, and sympathetic denervation leading to central hypovolaemia and reflex tachycardia. The golden standard for\n                    <jats:styled-content style=\"fixed-case\">POTS<\/jats:styled-content>\n                    diagnosis is head\u2010up tilt test with a non\u2010invasive beat\u2010to\u2010beat haemodynamic monitoring. Although long\u2010term prognosis of\n                    <jats:styled-content style=\"fixed-case\">POTS<\/jats:styled-content>\n                    is poorly explored, around 50% of patients spontaneously recover within 1\u20133\u00a0years. After the diagnosis has been established, patient should be thoroughly educated about non\u2010pharmacological measures alleviating the symptoms. Exercise training may be very effective and counteract deconditioning. In more symptomatic patients, different drugs directed at controlling heart rate, increasing peripheral vasoconstriction and intravascular volume can be tested. However, the overall effects of pharmacological therapy are modest and the most affected patients remain handicapped. Future efforts should focus on better understanding of\n                    <jats:styled-content style=\"fixed-case\">POTS<\/jats:styled-content>\n                    pathophysiology and designing randomized controlled trials for selection of more effective therapy.\n                  <\/jats:p>","DOI":"10.1111\/joim.12852","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T16:39:22Z","timestamp":1540831162000},"page":"352-366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":323,"title":["Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management"],"prefix":"10.1111","volume":"285","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5352-6327","authenticated-orcid":false,"given":"A.","family":"Fedorowski","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Lund University Malm\u00f6 Sweden"},{"name":"Department of Cardiology 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