{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T01:01:12Z","timestamp":1785200472461,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It has long been suggested that angiotensin\u2010converting enzyme inhibitors (<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>i) and angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> receptor blockers (<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>2s) have some degree of \u2018cross\u2010reactivity' in causing angioedema. Therefore, caution has been advised when switching patients with <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>i\u2010related angioedema to an <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To clarify whether <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>2s can be used safely in patients with a history of angioedema during <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>i treatment and to estimate the incidence rate of angioedema in patients subsequently treated with other antihypertensive drugs (beta\u2010adrenergic blockers, calcium channel blockers, thiazides and analogues) or no antihypertensives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a nationwide retrospective registry\u2010based cohort study of the Danish population during the period 1994 to 2016, and it uses Danish health registries. Propensity score adjusted and conventional proportional hazards regression models have been employed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1\u00a0106\u00a0024 <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>i users were identified. In total, 5\u00a0507 (0.5%) of these patients had experienced angioedema during <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>i treatment and were included in the study. The highest risk of angioedema recurrence was associated with continued <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>i use at an adjusted hazard ratio of 1.45 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.19 to 1.78). An inverse association was found between <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>2s and angioedema (adjusted hazard ratio, 0.39; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.30 to 0.51) compared with other antihypertensives (adjusted hazard ratios, 0.77 to 0.97).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with other antihypertensive drugs, <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>2s do not increase the incidence of angioedema in patients with previous <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>i\u2010related angioedema.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12867","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T19:23:44Z","timestamp":1543433024000},"page":"553-561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Angiotensin II receptor blockers are safe in patients with prior angioedema related to angiotensin\u2010converting enzyme inhibitors \u2013 a nationwide registry\u2010based cohort study"],"prefix":"10.1111","volume":"285","author":[{"given":"Eva Rye","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head &amp; Neck Surgery and Audiology Rigshospitalet, University of Copenhagen Blegdamsvej 9B 2100 Copenhagen East Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Potteg\u00e5rd","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Pharmacy University of Southern Denmark J.B. Winsl\u00f8ws Vej 19 5000 Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Bygum","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Center Odense University Hospital J.B. Winsl\u00f8wsvej 4, Entrance 142 5000 Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"von Buchwald","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head &amp; Neck Surgery and Audiology Rigshospitalet, University of Copenhagen Blegdamsvej 9B 2100 Copenhagen East Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preben","family":"Hom\u00f8e","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Maxillofacial Surgery Zealand University Hospital Lykkebaekvej 1 4600 K\u00f8ge Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Hallas","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Pharmacy University of Southern Denmark J.B. 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