{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T07:24:59Z","timestamp":1760081099417,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T00:00:00Z","timestamp":1547769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We conducted a retrospective survey within the European Society for Blood and Marrow Transplantation (<jats:styled-content style=\"fixed-case\">EBMT<\/jats:styled-content>) registry to assess the outcomes of cord blood transplantation (<jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content>) in secondary acute myeloid leukaemia (<jats:styled-content style=\"fixed-case\">sAML<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Inclusion criteria consisted of \u226518\u00a0years of age, <jats:styled-content style=\"fixed-case\">sAML<\/jats:styled-content>, first <jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content> between 2002 and 2016, and either first complete remission (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) or active disease at <jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred forty\u2010six patients met the study inclusion criteria. Status at transplantation was first <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a097), primary refractory <jats:styled-content style=\"fixed-case\">sAML<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a030) or relapsed (<jats:italic>n<\/jats:italic>\u00a0=\u00a019) <jats:styled-content style=\"fixed-case\">sAML<\/jats:styled-content>. Neutrophil engraftment was achieved in 118 patients while the remaining 25 patients (17%) failed to engraft. This includes 13% of patients transplanted in first <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> versus 30% of those transplanted with active disease (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). Two\u2010year incidences of relapse were 25% in first <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> patients versus 36% in those with advanced disease (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.06) while 2\u2010year incidences of nonrelapse mortality were 35% and 49% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), respectively. At 2\u2010year overall survival, leukaemia\u2010free survival and graft\u2010versus\u2010host disease (<jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>)\u2010free relapse\u2010free survival were 42% vs. 19% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), 40% vs. 16% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and 26% vs. 12% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) in first <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> patients versus those with advanced disease, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We report here the first study of <jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content> in a large cohort of <jats:styled-content style=\"fixed-case\">sAML<\/jats:styled-content> patients. Main observation was that <jats:styled-content style=\"fixed-case\">CBT<\/jats:styled-content> rescued approximately 40% of patients with <jats:styled-content style=\"fixed-case\">sAML<\/jats:styled-content> in first CR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12870","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T12:27:49Z","timestamp":1545136069000},"page":"446-454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cord blood transplantation is associated with good outcomes in secondary Acute Myeloid Leukaemia in first remission"],"prefix":"10.1111","volume":"285","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2944-3812","authenticated-orcid":false,"given":"F.","family":"Baron","sequence":"first","affiliation":[{"name":"Hematology, CHU and GIGA\u2010I3 University of Liege Liege Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Labopin","sequence":"additional","affiliation":[{"name":"AP\u2010HP H\u00e9matologie Clinique et Th\u00e9rapie Cellulaire H\u00f4pital Saint\u2010Antoine Paris France"},{"name":"EBMT Paris Office Hospital Saint Antoine Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7261-2765","authenticated-orcid":false,"given":"A.","family":"Ruggeri","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology IRCCS Bambino Ges\u00f9 Children's Hospital Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Volt","sequence":"additional","affiliation":[{"name":"Eurocord Hospital Saint Louis AP\u2010HP, and IUH University Paris VII France Monacord Centre Scientifique de Monaco Principaut\u00e9 de Monaco Monaco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mohty","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Clinique et Th\u00e9rapie Cellulaire H\u00f4pital Saint\u2010Antoine Universit\u00e9 Pierre &amp; Marie Curie and INSERM UMRs U938 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Blaise","sequence":"additional","affiliation":[{"name":"Transplant and cellular immunotherapy program Department of Hematology CRCM Inserm CNRS Aix Marseille Univ Institut Paoli Calmettes Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Chevallier","sequence":"additional","affiliation":[{"name":"Department of Hematology CHU of Nantes Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sanz","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitari i Polit\u00e8cnic La Fe Valencia CIBERONC Instituto Carlos III Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Fegueux","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'H\u00e9matologie Clinique CHU Lapeyronie Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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