{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:29:23Z","timestamp":1793212163915,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:00:00Z","timestamp":1555027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003506","name":"Helse- og Omsorgsdepartementet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003506","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2019,6]]},"abstract":"Abstract<\/jats:title>\n \n Background and objectives<\/jats:title>\n \n The 52\u2010week, randomized, double\u2010blind, noninferiority, government\u2010funded\n NOR<\/jats:styled-content>\n \u2010\n SWITCH<\/jats:styled-content>\n trial demonstrated that switching from infliximab originator to less expensive biosimilar\n CT<\/jats:styled-content>\n \u2010P13 was not inferior to continued treatment with infliximab originator. The\n NOR<\/jats:styled-content>\n \u2010\n SWITCH<\/jats:styled-content>\n extension trial aimed to assess efficacy, safety and immunogenicity in patients on\n CT<\/jats:styled-content>\n \u2010P13 throughout the 78\u2010week study period (maintenance group) versus patients switched to\n CT<\/jats:styled-content>\n \u2010P13 at week 52 (switch group). The primary outcome was disease worsening during follow\u2010up based on disease\u2010specific composite measures.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients were recruited from 24 Norwegian hospitals, 380 of 438 patients who completed the main study: 197 in the maintenance group and 183 in the switch group. In the full analysis set, 127 (33%) had Crohn's disease, 80 (21%) ulcerative colitis, 67 (18%) spondyloarthritis, 55 (15%) rheumatoid arthritis, 20 (5%) psoriatic arthritis and 31 (8%) chronic plaque psoriasis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Baseline characteristics were similar in the two groups at the time of switching (week 52). Disease worsening occurred in 32 (16.8%) patients in the maintenance group vs. 20 (11.6%) in the switch group (per\u2010protocol set). Adjusted risk difference was 5.9% (95%\n CI<\/jats:styled-content>\n \u22121.1 to 12.9). Frequency of adverse events, anti\u2010drug antibodies, changes in generic disease variables and disease\u2010specific composite measures were comparable between arms. The study was inadequately powered to detect noninferiority within individual diseases.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The\n NOR<\/jats:styled-content>\n \u2010\n SWITCH<\/jats:styled-content>\n extension showed no difference in safety and efficacy between patients who maintained\n CT<\/jats:styled-content>\n \u2010P13 and patients who switched from originator infliximab to\n CT<\/jats:styled-content>\n \u2010P13, supporting that switching from originator infliximab to\n CT<\/jats:styled-content>\n \u2010P13 is safe and efficacious.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/joim.12880","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T06:30:46Z","timestamp":1550125846000},"page":"653-669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Long\u2010term efficacy and safety of biosimilar infliximab (CT\u2010P13) after switching from originator infliximab: open\u2010label extension of the NOR\u2010SWITCH trial"],"prefix":"10.1111","volume":"285","author":[{"given":"G. L.","family":"Goll","sequence":"first","affiliation":[{"name":"Department of Rheumatology Diakonhjemmet Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. K.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sexton","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Diakonhjemmet Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. C.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Diakonhjemmet Hospital Oslo Norway"},{"name":"Research Support Services CTU Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Bolstad","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Oslo University Hospital Radiumhospitalet Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. A.","family":"Haavardsholm","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Diakonhjemmet Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. E. A.","family":"Lundin","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"},{"name":"Department of Gastroenterology Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"K.G. Jebsen Coeliac Disease Research Centre University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. S.","family":"Tveit","sequence":"additional","affiliation":[{"name":"Department of Dermatology Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lorentzen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. P.","family":"Berset","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology \u00c5lesund Hospital \u00c5lesund Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. T. S.","family":"Fevang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kalstad","sequence":"additional","affiliation":[{"name":"Department of Rheumatology University Hospital of Northern Norway Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ryggen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sankt Olav's Hospital Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Warren","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Oslo University Hospital Radiumhospitalet Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A.","family":"Klaasen","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Oslo University Hospital Radiumhospitalet Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8.","family":"Asak","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Gj\u00f8vik Hospital Gj\u00f8vik Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Baigh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Haugesund Hospital Haugesund Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. M.","family":"Blomgren","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Haugesund Hospital Haugesund Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8.","family":"Brenna","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sankt Olav's Hospital Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. J.","family":"Bruun","sequence":"additional","affiliation":[{"name":"Department of Rheumatology University Hospital of Northern Norway Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Dvergsnes","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology S\u00f8rlandet Hospital Kristiansand Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. O.","family":"Frigstad","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology B\u00e6rum Hospital B\u00e6rum Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. M.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Helgelandssykehuset Mo I Rana Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. S. H.","family":"Hatten","sequence":"additional","affiliation":[{"name":"Department of Dermatology F\u00f8rde Hospital F\u00f8rde Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Huppertz\u2010Hauss","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Telemark Hospital Skien Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology \u00d8stfold Hospital Fredrikstad Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. S.","family":"Hoie","sequence":"additional","affiliation":[{"name":"Department of Rheumatology S\u00f8rlandet Hospital Kristiansand Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Krogh","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Levanger Hospital Levanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. P.","family":"Midtgard","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Bod\u00f8 Hospital Bod\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Mielnik","sequence":"additional","affiliation":[{"name":"Department of Rheumatology F\u00f8rde Hospital F\u00f8rde Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Moum","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"},{"name":"Department of Gastroenterology Oslo University Hospital Ullev\u00e5l Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Noraberg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology S\u00f8rlandet Hospital Arendal Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Poyan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Kongsvinger Hospital Kongsvinger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Presteg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Lillehammer Hospital Lillehammer Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. U.","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Rheumatology \u00d8stfold Hospital Moss Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. K.","family":"Strand","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Revmatismesykehuset Lillehammer Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Skjetne","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sankt Olav's Hospital Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. A.","family":"Seeberg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Vestfold Hospital T\u00f8nsberg Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Torp","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hamar Hospital Hamar Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Ystr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Elverum Hospital Elverum Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Vold","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Bod\u00f8 Hospital Bod\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. C.","family":"Zettel","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Betanien Hospital Skien Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Waksvik","sequence":"additional","affiliation":[{"name":"Patient representative Norges Psoriasis\u2010 og eksemforbund Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Gulbrandsen","sequence":"additional","affiliation":[{"name":"Patient representative Landsforeningen for ford\u00f8yelsessykdommer Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hagfors","sequence":"additional","affiliation":[{"name":"Patient representative Norsk Revmatikerforbund Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"M\u00f8rk","sequence":"additional","affiliation":[{"name":"Institute of Cancer Research and Molecular Medicine Faculty of Medicine Norwegian University of Science and Technology Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Jahnsen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Akershus University Hospital L\u00f8renskog Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. K.","family":"Kvien","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Diakonhjemmet Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2006.052688"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203819"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex276"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-203090"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-203091"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207588"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex254"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13990"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208783"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208786"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211591"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2015.1103733"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx002.098"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30068-5"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206237"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev277"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210742"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-018-2418-4"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40324"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2017.1376110"},{"key":"e_1_2_9_22_1","first-page":"690","article-title":"Biosimilar infliximab in inflammatory bowel disease: outcomes of a managed switching programme","volume":"11","author":"Razanskaite V","year":"2017","journal-title":"J Crohn's Colitis"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2018.03.009"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoim.12880","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.12880","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joim.12880","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.12880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T14:42:30Z","timestamp":1694356950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.12880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,12]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/joim.12880"],"URL":"https:\/\/doi.org\/10.1111\/joim.12880","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,12]]},"assertion":[{"value":"2019-04-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}