{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:00:28Z","timestamp":1790226028673,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To assess the risk of incident cardiovascular disease in patients with primary Sj\u00f6gren's syndrome, overall and stratified by Ro\/<jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content> and La\/<jats:styled-content style=\"fixed-case\">SSB<\/jats:styled-content> autoantibody status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of patients with primary Sj\u00f6gren's syndrome in Sweden (<jats:italic>n<\/jats:italic>\u00a0=\u00a0960) and matched controls from the general population (<jats:italic>n<\/jats:italic>\u00a0=\u00a09035) were included, and data extracted from the National Patient Register to identify events of myocardial infarction, cerebral infarction and venous thromboembolism. Hazard ratios were estimated using cox proportional hazard regressions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median follow\u2010up of 9.5\u00a0years, the overall hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) was 1.6 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.2\u20132.1) for myocardial infarction, 1.2 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.9\u20131.7) for cerebral infarction and 2.1 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.6\u20132.9) for venous thromboembolism. Patients positive for both Ro\/<jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content> and La\/<jats:styled-content style=\"fixed-case\">SSB<\/jats:styled-content> autoantibodies had a substantially higher risk of cerebral infarction (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.7, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.0\u20132.9) and venous thromboembolism (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 3.1, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.9\u20134.8) than the general population. These risks were not significantly increased in Ro\/<jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content>\u2010 and La\/<jats:styled-content style=\"fixed-case\">SSB<\/jats:styled-content>\u2010negative patients. Among autoantibody\u2010positive patients, the highest <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> of cerebral infarction was seen after \u226510\u00a0years disease duration (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2.8, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.4\u20135.4), while the <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> for venous thromboembolism was highest 0\u20135\u00a0years after disease diagnosis (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 4.7, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.3\u20139.3) and remained high throughout disease duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Primary Sj\u00f6gren's syndrome is associated with a markedly increased risk of cardiovascular disease and the presence of Ro\/<jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content> and La\/<jats:styled-content style=\"fixed-case\">SSB<\/jats:styled-content> autoantibodies identify the subgroup of patients carrying the highest risk. These findings suggest that monitoring and prevention of cardiovascular disease in this patient group should be considered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12941","type":"journal-article","created":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T09:45:01Z","timestamp":1558777501000},"page":"458-468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Concomitant Ro\/<scp>SSA<\/scp> and La\/<scp>SSB<\/scp> antibodies are biomarkers for the risk of venous thromboembolism and cerebral infarction in primary Sj\u00f6gren's syndrome"],"prefix":"10.1111","volume":"286","author":[{"given":"J.","family":"Mofors","sequence":"first","affiliation":[{"name":"From the Division of Rheumatology Department of Medicine Karolinska Institutet Karolinska University Hospital Stockholm 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