{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:03:16Z","timestamp":1784354596181,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bradykinin\u2010mediated angioedema (AE) is a complication associated with thrombolysis for acute ischemic stroke. Risk factors are unknown and management is discussed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To clarify risk factors associated with bradykinin\u2010mediated AE after thrombolysis for acute ischemic stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a case\u2010control study conducted at a French reference centre for bradykinin angi\u0153dema, patients with thrombolysis for acute ischemic stroke and a diagnosis of bradykinin\u2010mediated angi\u0153dema, were compared to controls treated with thrombolysis treatment without angi\u0153dema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010three thrombolysis\u2010related AE were matched to 106 control subjects. The sites of attacks following thrombolysis for ischemic stroke mainly included tongue (34\/53, 64%) and lips (26\/53, 49%). The upper airways were involved in 37 (70%) cases. Three patients required mechanical ventilation. Patients with bradykinin\u2010mediated angi\u0153dema were more frequently women [33 (62%) vs. 44 (42%); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01], had higher frequency of prior ischemic stroke [12 (23%) vs. 9 (8%); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01], hypertension [46 (87%) vs. 70 (66%); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005], were more frequently treated with angiotensin\u2010converting enzyme inhibitor [37 (70%) vs. 28 (26%); <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001] and were more frequently hospitalized in intensive care medicine [<jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>; 11 (21%) vs. 5 (5%); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004]. In multivariate analysis, factors associated with thrombolysis\u2010related AE were female sex [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>), 3.04; 95% confident interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), 1.32\u20137.01; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009] and treatment with angiotensin\u2010converting enzyme inhibitors [(<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>), 6.08; 95% (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), 2.17\u201317.07; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This case\u2010control study points out angiotensin\u2010converting enzyme inhibitors and female sex as risk factors of bradykinin AE associated with thrombolysis for ischemic stroke.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.12962","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T16:59:41Z","timestamp":1563469181000},"page":"702-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Angioedema associated with thrombolysis for ischemic stroke: analysis of a case\u2010control study"],"prefix":"10.1111","volume":"286","author":[{"given":"C.","family":"Vigneron","sequence":"first","affiliation":[{"name":"From the AP\u2010HP M\u00e9decine Interne DHUi2B Centre de R\u00e9f\u00e9rence Associ\u00e9 sur les Angi\u0153d\u00e8mes \u00e0 Kinines (CR\u00e9Ak) H\u00f4pital Saint\u2010Antoine Universit\u00e9 Paris 6 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"L\u00e9cluse","sequence":"additional","affiliation":[{"name":"Neurologie CHU Angers Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Ronzi\u00e8re","sequence":"additional","affiliation":[{"name":"Neurologie CHU Pontchaillou Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bouillet","sequence":"additional","affiliation":[{"name":"M\u00e9decine Interne Centre de R\u00e9f\u00e9rence sur les Angi\u0153d\u00e8mes \u00e0 Kinines (CR\u00e9Ak) CHU de Grenoble Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Boccon\u2010Gibod","sequence":"additional","affiliation":[{"name":"M\u00e9decine Interne Centre de R\u00e9f\u00e9rence sur les Angi\u0153d\u00e8mes \u00e0 Kinines (CR\u00e9Ak) CHU de Grenoble Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gayet","sequence":"additional","affiliation":[{"name":"AP\u2010HM, M\u00e9decine Interne Centre de Comp\u00e9tence Angioed\u00e8mes non Histaminiques H\u00f4pital la Timone Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Doche","sequence":"additional","affiliation":[{"name":"AP\u2010HM Neurologie H\u00f4pital la Timone Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Smadja","sequence":"additional","affiliation":[{"name":"Neurologie CH Sud Francilien Corbeil\u2010Essonnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Di Legge","sequence":"additional","affiliation":[{"name":"Neurologie CH du Pays d'Aix\u2010CH Intercommunal Aix\u2010Pertuis Aix\u2010en\u2010Provence France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Dumont","sequence":"additional","affiliation":[{"name":"Neurologie CH Tourcoing Tourcoing France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gaudron","sequence":"additional","affiliation":[{"name":"Neurologie CHU Tours Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ion","sequence":"additional","affiliation":[{"name":"Neurologie CHU N\u00eemes N\u00eemes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Marcel","sequence":"additional","affiliation":[{"name":"Neurologie CH M\u00e9tropole Savoie Chamb\u00e9ry France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"S\u00e9vin","sequence":"additional","affiliation":[{"name":"Neurologie Institut du Thorax et du Syst\u00e8me Nerveux CHU Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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