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The condition is associated with increased morbidity and mortality that can be mitigated by treatments that result in sustained endocrine remission. Transsphenoidal pituitary surgery (<jats:styled-content style=\"fixed-case\">TSS<\/jats:styled-content>) remains the mainstay of treatment for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> but requires considerable neurosurgical expertise and experience in order to optimize patient outcomes. Up to 90% of patients with microadenomas (tumour below 1\u00a0cm in largest diameter) and 65% of patients with macroadenomas (tumour at or above 1\u00a0cm in greatest diameter) achieve endocrine remission after <jats:styled-content style=\"fixed-case\">TSS<\/jats:styled-content> by an experienced surgeon. Patients who are not in remission postoperatively or those who relapse may benefit from undergoing a second pituitary operation. Alternatively, radiation therapy to the sella with interim medical therapy, or bilateral adrenalectomy, can be effective as definitive treatments of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>. Medical therapy is currently adjunctive in most patients with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> and is generally prescribed to patients who are about to receive radiation therapy and will be awaiting its salutary effects to occur. Available treatment options include steroidogenesis inhibitors, centrally acting agents and glucocorticoid receptor antagonists. Several novel agents are in clinical trials and may eventually constitute additional treatment options for this serious condition.<\/jats:p>","DOI":"10.1111\/joim.12975","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T03:28:15Z","timestamp":1568258895000},"page":"526-541","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Current management of Cushing's disease"],"prefix":"10.1111","volume":"286","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8867-607X","authenticated-orcid":false,"given":"N. A.","family":"Tritos","sequence":"first","affiliation":[{"name":"Neuroendocrine Unit Massachusetts General Hospital and Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. M. 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