{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:35:17Z","timestamp":1790523317652,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is a documented association between drug exposure and sarcoidosis\u2010like reactions. In this study, we used the largest pharmacovigilance database to describe drug\u2010induced sarcoidosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data were collected from the World Health Organization (WHO) pharmacovigilance database (VigiBase). We excluded steroids and vaccines from the analysis. The primary end\u2010point was the lower end\u2010point of the 95% credibility interval for the information component (IC\n                      <jats:sub>025<\/jats:sub>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 127 reports had significant IC\n                      <jats:sub>025<\/jats:sub>\n                      values for drug\u2010induced sarcoidosis, and 110 were included in the final analysis, accounting for 2425 adverse drug reactions. Overall, 2074 (85.5%) reactions were considered \u2018serious\u2019 and 86 (3.5%) were fatal. Most of the drugs that led to sarcoidosis adverse reactions were TNF\u2010alpha antagonists, interferon or peg\u2010interferon therapeutics, and immune checkpoint inhibitors. Other biologic drugs were less frequently associated with sarcoidosis adverse events. Cancer\u2010targeted therapies such as BRAF or MEK inhibitors were associated with sarcoidosis reactions in 37 cases. Pulmonary hypertension drugs were also reported for drug\u2010induced sarcoidosis. Amongst the 55 drugs considered as potential sarcoidosis inducers, 25 (45.4%) were never reported in Medline as drug\u2010induced sarcoidosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We provide a detailed list of suspected drugs associated with drug\u2010induced sarcoidosis that will improve the recognition of this drug\u2010induced adverse event.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.12991","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T03:45:26Z","timestamp":1571111126000},"page":"356-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Drug\u2010induced sarcoidosis: an overview of the WHO pharmacovigilance database"],"prefix":"10.1111","volume":"288","author":[{"given":"F.","family":"Cohen Aubart","sequence":"first","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris, Service de M\u00e9decine Interne 2 Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares et Histiocytoses, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Lhote","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris, Service de M\u00e9decine Interne 2 Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares et Histiocytoses, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Amoura","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris, Service de M\u00e9decine Interne 2 Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares et Histiocytoses, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Valeyre","sequence":"additional","affiliation":[{"name":"Service de Pneumologie Assistance Publique\u2010H\u00f4pitaux de Paris H\u00f4pital Avicenne Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Haroche","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris, Service de M\u00e9decine Interne 2 Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares et Histiocytoses, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Amoura","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris, Service de M\u00e9decine Interne 2 Centre National de R\u00e9f\u00e9rence Maladies Syst\u00e9miques Rares et Histiocytoses, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Lebrun\u2010Vignes","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris Service de Pharmacovigilance de la piti\u00e9\u2010Salp\u00eatri\u00e8re Paris 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