{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:44:21Z","timestamp":1790653461657,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Periodontal disease is associated with cardiovascular disease (CVD) but it is unknown if periodontal disease severity is associated with asymptomatic carotid plaque. The aim of the current population\u2010based, observational study was to investigate if signs of periodontal disease are associated with the occurrence of carotid plaque and total plaque area (TPA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Malm\u00f6 Offspring Study (MOS) is a population\u2010based study. MOS participants underwent a thorough cardiovascular phenotyping, including carotid ultrasonography. The Malm\u00f6 Offspring Dental Study (MODS) invited participants of MOS for dental examination, including periodontal charting. Multivariable regression models were used to analyse the presence of carotid plaque and TPA in relation to periodontal parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In all, 831 MODS participants were recruited, out of which 495 belonged to the children generation with mean age of 53\u00a0years, 63% had carotid plaque and 38% had moderate or severe periodontal disease. In models adjusted for CVD risk factors, the OR for having carotid plaque in subjects with vs without periodontal disease was 1.75 (95% CI: 1.11\u20132.78). In a linear model with TPA as dependent and number of periodontal pockets\u00a0\u2265\u00a04\u00a0mm as independent variable, the adjusted beta\u2010coefficient was 0.34 mm\n                      <jats:sup>2<\/jats:sup>\n                      (95% CI 0.16\u20130.52).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Individuals within the highest quartile of periodontal pockets are expected to have 9\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      larger TPA compared to those without pockets. Our results suggest that intervention studies addressing periodontal disease could be useful for prevention of CVD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.12998","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T05:16:41Z","timestamp":1571635001000},"page":"301-309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Periodontal disease is associated with carotid plaque area: the Malm\u00f6 Offspring Dental Study (MODS)"],"prefix":"10.1111","volume":"287","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8298-539X","authenticated-orcid":false,"given":"D.","family":"J\u00f6nsson","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Odontology Malm\u00f6 University Malm\u00f6 Sweden"},{"name":"Swedish Dental Service of Sk\u00e5ne Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Orho\u2010Melander","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University Skane University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. T.","family":"Demmer","sequence":"additional","affiliation":[{"name":"School of Public Health University of Minnesota Minneapolis MN USA"},{"name":"Mailman School of Public Health Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Engstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University Skane University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Melander","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University Skane University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Klinge","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Odontology Malm\u00f6 University Malm\u00f6 Sweden"},{"name":"Division of Periodontology Department of Dental Medicine Karolinska Institutet Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University Skane University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512457373"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.020324"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063186"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140153"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu299"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2011.02373.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000155018.67835.1a"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2008.07.008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.06.044"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.589754"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2005.01485.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.06.002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.7.793"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1993.tb00647.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060264"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000136767.71518.36"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.173609"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.07.006"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343145"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2005.00141.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510375281"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077441"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/hq1101.097803"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.577973"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12782"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.3060"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.720847"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67663-5"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000042207.16156.B9"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.12998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joim.12998","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.12998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T02:21:00Z","timestamp":1694053260000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.12998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,13]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/joim.12998"],"URL":"https:\/\/doi.org\/10.1111\/joim.12998","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,13]]},"assertion":[{"value":"2019-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}