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Just before, in 2006, the Food and Drug Administration had approved Gardasil, the first vaccine against HPV16, 18, 6 and 11, for preventive vaccination women against cervical cancer. Concurrently, some Western countries, where smoking was decreasing, disclosed an epidemic increase in the incidence of OPSCC, especially of TSCC and base of tongue cancer (BOTSCC), together accounting for 80\u201390% of all OPSCCs, and mainly affecting men. The epidemic was later revealed to be due to a rise in HPV\u2010positive cases, and scientists in the field suggested HPV vaccination also of boys. Globally, there are roughly 96\u00a0000 incident OPSCC cases\/year of which 20\u201324% are caused by HPV, thereby accounting for around 22 000 OPSCC cases annually. Of these cases, 80\u201390% are due to HPV16 infection and would be prevented with the presently registered HPV vaccines. In Western countries, such as Sweden (with almost 400 TSCC and BOTSCC cases per year) and the United States, HPV prevalence in OPSCC is higher and around 70%. HPV vaccination of girls has been initiated in many countries, and the vaccines have been efficient and their side effects limited. HPV vaccination of boys has, however, been the exception, but should definitely not be delayed any further. It would benefit both girls and boys directly, and result in better and more robust herd immunity. Today, we have the possibility to eliminate several high\u2010risk HPV types in the younger generations and avoid more than 600\u00a0000 cancer cases annually worldwide, and this possibility should be embraced by offering global pan\u2010gender HPV vaccination.<\/jats:p>","DOI":"10.1111\/joim.13010","type":"journal-article","created":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T09:00:53Z","timestamp":1573894853000},"page":"134-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["A global epidemic increase of an HPV\u2010induced tonsil and tongue base cancer \u2013 potential benefit from a pan\u2010gender use of HPV vaccine"],"prefix":"10.1111","volume":"287","author":[{"given":"A.","family":"N\u00e4sman","sequence":"first","affiliation":[{"name":"From the Department of Oncology\u2010Pathology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Microbiology Tumor Biology and Cell Biology Centre for Translational Microbiome Research (CTMR) Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7022-2424","authenticated-orcid":false,"given":"T.","family":"Dalianis","sequence":"additional","affiliation":[{"name":"From the Department of Oncology\u2010Pathology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,9]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.9.709"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000520)89:3<300::AID-IJC14>3.0.CO;2-G"},{"key":"e_1_2_14_4_1","unstructured":"IARC.A review of human carcinogenes. 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