{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:18:09Z","timestamp":1788347889180,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF18OC0052917"],"award-info":[{"award-number":["NNF18OC0052917"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Obesity is associated with metabolic abnormalities that predispose patients to increased cancer risk. Contemporary data on the long\u2010term risk of specific cancers are sparse among patients with hospital\u2010diagnosed overweight and obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the overall cancer incidence and specific site\u2010related cancer incidences among patients with overweight and obesity, compared to the general Danish population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For this 40\u2010year (1977\u20132016), nationwide, Danish cohort study, we reviewed medical databases to identify individuals with hospital\u2010based overweight and obesity diagnoses. We computed age\u2010 and gender\u2010standardized incidence ratios (SIRs) for subsequent cancer compared to the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed 20\u00a0706 cancers among 313\u00a0321 patients diagnosed with overweight and obesity (median age 43\u00a0years; median follow\u2010up 6.7\u00a0years, range 1\u201340\u00a0years) compared to the 18\u00a0480 cancers expected; thus, the SIR was 1.12 [95% confidence interval (95% CI): 1.11\u20131.14]. The SIR associated with overweight and obesity was increased with concomitant comorbidities, like type 2 diabetes (SIR: 1.18; 95% CI: 1.13\u20131.23) and alcoholism\u2010related diseases (SIR: 1.62; 95% CI: 1.45\u20131.82). The SIR was 1.31 (95% CI: 1.28\u20131.34) for cancers previously identified as obesity\u2010related, including pancreatic (SIR: 1.38; 95% CI; 1.27\u20131.49) and postmenopausal breast cancer (SIR: 1.14; 95% CI: 1.09\u20131.19). Obesity\/overweight status also elevated the SIRs for haematological (SIR: 1.24; 95% CI: 1.18\u20131.29) and neurological cancers (SIR: 1.19; 95% CI: 1.11\u20131.27]. In contrast, SIRs were 1.01 (95% CI: 0.97\u20131.05) for immune\u2010related cancers, 0.88 (95% CI: 0.82\u20130.95) for malignant melanoma, and 0.88 (95% CI: 0.85\u20130.92) for hormone\u2010related cancers, other than postmenopausal breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this large cohort study, overweight and obesity was associated with increased risk of several common cancers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13013","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T05:02:00Z","timestamp":1578459720000},"page":"435-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Hospital\u2010diagnosed overweight and obesity related to cancer risk: a 40\u2010year Danish cohort study"],"prefix":"10.1111","volume":"287","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8681-6822","authenticated-orcid":false,"given":"S. B.","family":"Gribsholt","sequence":"first","affiliation":[{"name":"From the Department of Clinical Epidemiology Aarhus University Hospital Aarhus N Denmark"},{"name":"Department of Endocrinology and Internal Medicine Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9738-2284","authenticated-orcid":false,"given":"D.","family":"Cronin\u2010Fenton","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Epidemiology Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Veres","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Epidemiology Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9135-3474","authenticated-orcid":false,"given":"R. W.","family":"Thomsen","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Epidemiology Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. G.","family":"Ording","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Epidemiology Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8886-9736","authenticated-orcid":false,"given":"B.","family":"Richelsen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Aarhus Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-7040","authenticated-orcid":false,"given":"H. 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