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The present study assessed the association between family history and prognosis and, based on current evidence, explored whether this association was modified by age at diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using data from the Swedish Colorectal Cancer Registry (SCRCR) linked with the Multigeneration Register and the National Cancer Register, we identified 31\u00a0801 patients with a CRC diagnosed between 2007 and 2016. The SCRCR is a clinically rich database which includes information on the cancer stage, grade, location, treatment, complications and postoperative follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We estimated excess mortality rate ratios (EMRR) for relative survival and hazard ratios (HR) for disease\u2010free survival with 95% confidence intervals (CIs) using flexible parametric models. We found no association between family history and relative survival (EMRR\u00a0=\u00a00.96, 95% CIs: 0.89\u20131.03, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.21) or disease\u2010free survival (HR\u00a0=\u00a00.98, 95% CIs: 0.91\u20131.06, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.64). However, age was found to modify the impact of family history on prognosis. Young patients (&lt;50 at diagnosis) with a positive family history had less advanced (i.e. stages I and II) cancers than those with no family history (OR\u00a0=\u00a00.71, 95% CI: 0.56\u20130.89, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) and lower excess mortality even after adjusting for cancer stage (EMMR\u00a0=\u00a00.63, 95% CIs: 0.47\u20130.84, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that young individuals with a family history of CRC may have greater health awareness, attend opportunistic screening and adopt lifestyle changes, leading to earlier diagnosis and better prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13036","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T17:53:40Z","timestamp":1580752420000},"page":"723-733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Family history of colorectal cancer and survival: a Swedish population\u2010based study"],"prefix":"10.1111","volume":"287","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2054-7930","authenticated-orcid":false,"given":"F.","family":"Pesola","sequence":"first","affiliation":[{"name":"From the School of Cancer &amp; Pharmaceutical Sciences King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Eloranta","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna Division of Clinical Epidemiology Karolinska Institutet and Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Martling","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Saraste","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. E.","family":"Smedby","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna Division of Clinical Epidemiology Karolinska Institutet and Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j2497"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10332"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007133430201"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28397"},{"key":"e_1_2_7_7_1","first-page":"9292","article-title":"Familial colorectal cancer: a review","volume":"20","author":"Armelao F","year":"2014","journal-title":"World J Gastroenterol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-27-39"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23294"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30476"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12120"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1470"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70282-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.07.055"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.91"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-009-9286-0"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/24.5.888"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0587"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-008-9190-z"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jjco.a039659"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2003.12.020"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-12-370"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9465-x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2018.1529425"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9166"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm234"},{"key":"e_1_2_7_27_1","unstructured":"2008 Karolinska Institutet Sweden Stockholm M Leu Truncation and Missing Family Links in Population\u2010Based Registers"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802247664"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn290"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13053-018-0098-9"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1597"},{"key":"e_1_2_7_32_1","unstructured":"Human Mortality Database.University of California Berkeley (USA) and Max Planck Institute for Demographic Research (Germany).http:\/\/wwwmortalityorgdata download in April 2018."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0900900206"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2017.02.005"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4067"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X0500500204"},{"key":"e_1_2_7_37_1","unstructured":"StataCorp.Stata Statistical Software: Release 14.College Station TX:StataCorp LP 2015."},{"key":"e_1_2_7_38_1","unstructured":"LambertPC.STPM2: Stata module to estimate flexible parametric survival models. 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