{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:12:14Z","timestamp":1790741534192,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,15]],"date-time":"2020-03-15T00:00:00Z","timestamp":1584230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002706","name":"AFA F\u00f6rs\u00e4kring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In the present case\u2013control study, we describe the associations between leukocyte subsets in blood and early, screening\u2010detected AAA in men. An abdominal aortic aneurysm (AAA) may result in a life\u2010threatening rupture of the aortic wall. The trigger for AAA formation remains unknown, but the vascular adventitia of advanced AAAs is infiltrated by various leukocytes, indicating that the pathogenesis may involve inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In Sweden, all 65\u2010year\u2010old men are invited to an ultrasound examination for detection of AAA. At the Gothenburg screening site, 16\u00a0256 men were examined in 2013\u20132017, 1.2% of whom had an AAA (diameter of the infrarenal aorta \u226530\u00a0mm). All men with AAA at screening as well as a randomized selection of AAA\u2010free screened men were invited to participate in a case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median diameter of AAAs was 33\u00a0mm. Men with an AAA (<jats:italic>n<\/jats:italic>\u00a0=\u00a0151) had a higher frequency of smoking, hypertension and statin use than controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a0224). Blood levels of neutrophils, lymphocytes, monocytes and basophils were higher in individuals with an AAA, but eosinophil count did not differ from controls. Odds ratios (95% confidence interval) for AAA were 8.6 (4.2\u201317.4), 3.5 (1.9\u20136.6) and 3.3 (1.8\u20136.3) for the highest versus lowest quartile of neutrophils, lymphocytes and monocytes, respectively. For neutrophils and lymphocytes, the association with AAA remained significant after adjustment for smoking and other known risk factors\/markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Several, but not all, subsets of circulating leukocytes are associated with screening\u2010detected AAA in men, which is insufficiently explained by associations with smoking and other confounders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13040","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T06:00:27Z","timestamp":1584338427000},"page":"345-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Leukocyte subsets and abdominal aortic aneurysms detected by screening in men"],"prefix":"10.1111","volume":"288","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9438-1518","authenticated-orcid":false,"given":"M.","family":"Langenski\u00f6ld","sequence":"first","affiliation":[{"name":"From the Vascular Surgery Research Group Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2307-7062","authenticated-orcid":false,"given":"K.","family":"Smidfelt","sequence":"additional","affiliation":[{"name":"From the Vascular Surgery Research Group Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2670-2268","authenticated-orcid":false,"given":"J.","family":"Nordanstig","sequence":"additional","affiliation":[{"name":"From the Vascular Surgery Research Group Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4289-5722","authenticated-orcid":false,"given":"G.","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory for Cardiovascular and Metabolic Research Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8318-0486","authenticated-orcid":false,"given":"\u00c5.","family":"Tivesten","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory for Cardiovascular and Metabolic Research Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg 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