{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:26:38Z","timestamp":1792193198985,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swedish Research Council through the Swedish Initiative for Research on Microdata in the Social and Medical Sciences (SIMSAM\/VRREG) framework grant","award":["2013-05187"],"award-info":[{"award-number":["2013-05187"]}]},{"name":"Swedish Research Council through the Swedish Initiative for Research on Microdata in the Social and Medical Sciences (SIMSAM\/VRREG) framework grant","award":["2019-00193"],"award-info":[{"award-number":["2019-00193"]}]},{"DOI":"10.13039\/501100001862","name":"The Swedish Research Council","doi-asserted-by":"crossref","award":["2012-2392"],"award-info":[{"award-number":["2012-2392"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001862","name":"The Swedish Research Council","doi-asserted-by":"crossref","award":["2018-02527"],"award-info":[{"award-number":["2018-02527"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Swedish state under an agreement between the Swedish government and the County Councils Concerning Economic Support of Research and Education of Doctors","award":["ALFGBG-427301"],"award-info":[{"award-number":["ALFGBG-427301"]}]},{"name":"the Swedish state under an agreement between the Swedish government and the County Councils Concerning Economic Support of Research and Education of Doctors","award":["ALFGBG-442611"],"award-info":[{"award-number":["ALFGBG-442611"]}]},{"name":"the Swedish state under an agreement between the Swedish government and the County Councils Concerning Economic Support of Research and Education of Doctors","award":["ALFGBG-717211"],"award-info":[{"award-number":["ALFGBG-717211"]}]},{"name":"Swedish Heart and Lung Foundation","award":["2015-0438"],"award-info":[{"award-number":["2015-0438"]}]},{"name":"Swedish Heart and Lung Foundation","award":["2018-0589"],"award-info":[{"award-number":["2018-0589"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>As the population of obese and severely obese young adults grows, it is becoming increasingly important to recognize the long\u2010term risks associated with adolescent obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to determine the association between body mass index (BMI) in young men at enlistment for military service and later risk of venous thromboembolism (VTE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nationwide register\u2010based prospective cohort study of men enlisting 1969 to 2005, followed through the Swedish National Patient and Cause of Death registries. We identified 1\u00a0639\u00a0838 men (mean age, 18.3\u00a0years) free of prior venous thromboembolism, of whom 29\u00a0342\u00a0were obese (BMI 30 to &lt;35\u00a0kg\u00a0m<jats:sup>\u22122<\/jats:sup>) and 7236 severely obese (BMI\u00a0\u2265\u00a035\u00a0kg\u00a0m<jats:sup>\u22122<\/jats:sup>). The participants were followed until a first registered diagnosis of VTE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median follow\u2010up of 28\u00a0years (interquartile interval, 20 to 36\u00a0years), 11\u00a0395 cases of deep vein thrombosis and 7270 cases of pulmonary embolism were recorded. Compared with men with a BMI of 18.5 to &lt;20\u00a0kg\u00a0m<jats:sup>\u22122<\/jats:sup>, men with higher BMI in young adulthood showed an incrementally increasing risk of VTE that was moderately but significantly increased already at normal BMI levels. Adolescent obese men with a BMI of 30 to 35\u00a0kg\u00a0m<jats:sup>\u22122<\/jats:sup> had an adjusted hazard ratio of 2.93 (95% confidence interval, 2.65 to 3.24) for VTE. Severely obese men with a BMI of \u226535\u00a0kg\u00a0m<jats:sup>\u22122<\/jats:sup> had a hazard ratio of 4.95 (95% confidence interval, 4.16 to 5.90).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Men who were obese or severely obese in young adulthood had a marked increase in risk of VTE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13044","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T07:46:57Z","timestamp":1587973617000},"page":"734-745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Obesity in adolescent men increases the risk of venous thromboembolism in adult life"],"prefix":"10.1111","volume":"287","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6563-0893","authenticated-orcid":false,"given":"K.","family":"Glise Sandblad","sequence":"first","affiliation":[{"name":"From the Department of Medicine, Geriatrics and Emergency Medicine Region V\u00e4stra G\u00f6taland Sahlgrenska University Hospital\/\u00d6stra Gothenburg Sweden"},{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jern","sequence":"additional","affiliation":[{"name":"The Wallenberg Laboratory for Cardiovascular Research Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0323-1061","authenticated-orcid":false,"given":"M.","family":"\u00c5berg","sequence":"additional","affiliation":[{"name":"Department of Public Health and Community Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2167-6822","authenticated-orcid":false,"given":"J.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Public Health and Community Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Infectious Diseases Region V\u00e4stra G\u00f6taland Sahlgrenska University Hospital\/\u00d6stra Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8509-7603","authenticated-orcid":false,"given":"K.","family":"Tor\u00e9n","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Medicine School of Public Health and Community Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-0422","authenticated-orcid":false,"given":"M.","family":"Lindgren","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Geriatrics and Emergency Medicine Region V\u00e4stra G\u00f6taland Sahlgrenska University Hospital\/\u00d6stra Gothenburg Sweden"},{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3667-589X","authenticated-orcid":false,"given":"M.","family":"Adiels","sequence":"additional","affiliation":[{"name":"Centre for Applied Biostatistics, Occupational and Environmental Medicine University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6323-0506","authenticated-orcid":false,"given":"P.O.","family":"Hansson","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Geriatrics and Emergency Medicine Region V\u00e4stra G\u00f6taland Sahlgrenska University Hospital\/\u00d6stra Gothenburg Sweden"},{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5409-6605","authenticated-orcid":false,"given":"A.","family":"Rosengren","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30054-X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32129-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2018.05.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.06.033"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.709204"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01647-2019"},{"issue":"23","key":"e_1_2_9_8_1","first-page":"I9","article-title":"Risk factors for venous thromboembolism","volume":"107","author":"Anderson FA","year":"2003","journal-title":"Circulation"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(70)80023-X"},{"key":"e_1_2_9_10_1","first-page":"63","article-title":"Venous thromboembolism in the morbidly obese","volume":"147","author":"Printen KJ","year":"1978","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.6.809"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12299"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.16.1886"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.863241"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9950-z"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.4537"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011407"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2006.00291.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494807085185"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.10.024"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-002698"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-00329"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu041"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1163"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487317689974"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.03.018"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-008864"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S177058"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.83"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH17-08-0531"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.06.012"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-017-1811-x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2009.00593.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.04.023"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.03.021"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12334"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-450"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-017-0316-1"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoim.13044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.13044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joim.13044","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.13044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T10:25:13Z","timestamp":1693995913000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.13044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,27]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/joim.13044"],"URL":"https:\/\/doi.org\/10.1111\/joim.13044","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,27]]},"assertion":[{"value":"2020-04-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}