{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:58:51Z","timestamp":1790135931937,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC CoG 818715, SECRETE\u2010HF"],"award-info":[{"award-number":["ERC CoG 818715, SECRETE\u2010HF"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP7\u2010242209\u2010BIOSTAT\u2010CHF"],"award-info":[{"award-number":["FP7\u2010242209\u2010BIOSTAT\u2010CHF"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is increasing recognition that heart failure (HF) and cancer are conditions with a number of shared characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To explore the association between tumour biomarkers and HF outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In 2,079 patients of BIOSTAT\u2010CHF cohort, we measured six established tumour biomarkers: CA125, CA15\u20103, CA19\u20109, CEA, CYFRA 21\u20101 and AFP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During a median follow\u2010up of 21\u00a0months, 555 (27%) patients reached the primary end\u2010point of all\u2010cause mortality. CA125, CYFRA 21\u20101, CEA and CA19\u20109 levels were positively correlated with NT\u2010proBNP quartiles (all\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001,\n                      <jats:italic>P<\/jats:italic>\n                      for trend\u00a0&lt;\u00a00.001) and were, respectively, associated with a hazard ratio of 1.17 (95% CI 1.12\u20131.23;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001), 1.45 (95% CI 1.30\u20131.61;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001), 1.19 (95% CI 1.09\u20131.30;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.006) and 1.10 (95% CI 1.05\u20131.16;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) for all\u2010cause mortality after correction for BIOSTAT risk model (age, BUN, NT\u2010proBNP, haemoglobin and beta blocker). All tumour biomarkers (except AFP) had significant associations with secondary end\u2010points (composite of all\u2010cause mortality and HF hospitalization, HF hospitalization, cardiovascular (CV) mortality and non\u2010CV mortality). ROC curves showed the AUC of CYFRA 21\u20101 (0.64) had a noninferior AUC compared with NT\u2010proBNP (0.68) for all\u2010cause mortality (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.08). A combination of CYFRA 21\u20101 and NT\u2010proBNP (AUC\u00a0=\u00a00.71) improved the predictive value of the model for all\u2010cause mortality (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0002 compared with NT\u2010proBNP).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Several established tumour biomarkers showed independent associations with indices of severity of HF and independent prognostic value for HF outcomes. This demonstrates that pathophysiological pathways sensed by these tumour biomarkers are also dysregulated in HF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.13053","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:01:38Z","timestamp":1588723298000},"page":"207-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Tumour biomarkers: association with heart failure outcomes"],"prefix":"10.1111","volume":"288","author":[{"given":"C.","family":"Shi","sequence":"first","affiliation":[{"name":"From the Department of Cardiology Uni University Medical Center Groningen Groningen the Netherlands"},{"name":"University of Groningen University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. H.","family":"van der Wal","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology Uni University Medical Center Groningen Groningen the Netherlands"},{"name":"University of Groningen University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. H. W.","family":"Sillj\u00e9","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology Uni University Medical Center Groningen Groningen the Netherlands"},{"name":"University of Groningen University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. M.","family":"Dokter","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology Uni University Medical Center Groningen Groningen the Netherlands"},{"name":"University of Groningen University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"van den Berg","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology Uni University Medical Center Groningen Groningen the Netherlands"},{"name":"University of Groningen University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Huizinga","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology Uni University Medical Center Groningen Groningen the Netherlands"},{"name":"University of Groningen University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vriesema","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology Uni University Medical Center Groningen Groningen the Netherlands"},{"name":"University of Groningen University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Post","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology Uni University Medical Center Groningen Groningen the Netherlands"},{"name":"University of Groningen University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Department of Cardiology Berlin\u2010Brandenburg Center for Regenerative Therapies German Centre for Cardiovascular Research (DZHK) Partner site Berlin Charit\u00e9 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G.","family":"Cleland","sequence":"additional","affiliation":[{"name":"National Heart &amp; Lung Institute Royal Brompton &amp; Harefield Hospitals Imperial College London UK"},{"name":"Robertson Institute of Biostatistics and Clinical Trials Unit University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. L.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences University of Leicester Leicester UK"},{"name":"NIHR Leicester Biomedical Research Centre Glenfield Hospital Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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