{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T22:51:40Z","timestamp":1794091900447,"version":"4.8.0"},"reference-count":165,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T00:00:00Z","timestamp":1586217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Intern Med"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mitochondrial disease presenting in childhood is characterized by clinical, biochemical and genetic complexity. Some children are affected by canonical syndromes, but the majority have nonclassical multisystemic disease presentations involving virtually any organ in the body. Each child has a unique constellation of clinical features and disease trajectory, leading to enormous challenges in diagnosis and management of these heterogeneous disorders. This review discusses the classical mitochondrial syndromes presenting most frequently in childhood and then presents an organ\u2010based perspective including systems less frequently linked to mitochondrial disease, such as skin and hair abnormalities and immune dysfunction. An approach to diagnosis is then presented, encompassing clinical evaluation and biochemical, neuroimaging and genetic investigations, and emphasizing the problem of phenocopies. The impact of next\u2010generation sequencing is discussed, together with the importance of functional validation of novel genetic variants never previously linked to mitochondrial disease. The review concludes with a brief discussion of currently available and emerging therapies. The field of mitochondrial medicine has made enormous strides in the last 30\u00a0years, with approaching 400 different genes across two genomes now linked to primary mitochondrial disease. However, many important questions remain unanswered, including the reasons for tissue specificity and variability of clinical presentation of individuals sharing identical gene defects, and a lack of disease\u2010modifying therapies and biomarkers to monitor disease progression and\/or response to treatment.<\/jats:p>","DOI":"10.1111\/joim.13054","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T10:43:00Z","timestamp":1584355380000},"page":"609-633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":184,"title":["Mitochondrial disease in children"],"prefix":"10.1111","volume":"287","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2088-730X","authenticated-orcid":false,"given":"S.","family":"Rahman","sequence":"first","affiliation":[{"name":"Mitochondrial Research Group UCL Great Ormond Street Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,7]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30727-X"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:BOLI.0000031098.41409.55"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2018-105800"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1931.02230030027002"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.14.3.216"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1958.00940080296016"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80286-3"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(80)90031-3"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160409"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-101159"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-011-9413-6"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.12.023"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-017-0122-7"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2007.053116"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy374"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-018-0218-2"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.6.1783"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.147983"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/430843"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-017-0027-5"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0101-0"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-019-0613-z"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp221"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22111"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt309"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.8.1327"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-014-9778-4"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-23"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.06.014"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.06.013"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-014-0119-3"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390311"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500030042009"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.35"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-49771-5_14"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410010104"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2010.04.001"},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2010.088328"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909303411404"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0496-410"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.1086\/302590"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.5.644"},{"key":"e_1_2_16_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01049"},{"key":"e_1_2_16_45_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31823a0c7f"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/348651a0"},{"key":"e_1_2_16_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2006.12.004"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-303528"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90218-8"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318294b44c"},{"key":"e_1_2_16_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(88)90229-8"},{"key":"e_1_2_16_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12551"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.14"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-303232"},{"key":"e_1_2_16_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201002"},{"key":"e_1_2_16_56_1","volume-title":"GeneReviews\u00ae [Internet","author":"Yu\u2010Wai\u2010Man P","year":"1993"},{"key":"e_1_2_16_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq276"},{"key":"e_1_2_16_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.13.6206"},{"key":"e_1_2_16_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067210201200615"},{"key":"e_1_2_16_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10435"},{"key":"e_1_2_16_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14485"},{"key":"e_1_2_16_62_1","first-page":"1732","article-title":"Mitochondrial and Metabolic Myopathies","volume":"25","author":"Cohen BH","year":"2019","journal-title":"Continuum (Minneap Minn)"},{"key":"e_1_2_16_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2016.07.014"},{"key":"e_1_2_16_64_1","volume-title":"GeneReviews\u00ae [Internet]","author":"Thorburn DR","year":"1993"},{"key":"e_1_2_16_65_1","doi-asserted-by":"publisher","DOI":"10.1086\/506913"},{"key":"e_1_2_16_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2019.10.010"},{"key":"e_1_2_16_67_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182698d8d"},{"key":"e_1_2_16_68_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a4a518"},{"key":"e_1_2_16_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx369"},{"key":"e_1_2_16_70_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-306387"},{"key":"e_1_2_16_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1625-2"},{"key":"e_1_2_16_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25550"},{"key":"e_1_2_16_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gim.0000237781.10594.d1"},{"key":"e_1_2_16_74_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0806396"},{"key":"e_1_2_16_75_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2011-000411"},{"key":"e_1_2_16_76_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055262"},{"key":"e_1_2_16_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25110"},{"key":"e_1_2_16_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.973"},{"key":"e_1_2_16_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-016-0477-0"},{"key":"e_1_2_16_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000535"},{"key":"e_1_2_16_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp186"},{"key":"e_1_2_16_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.12.038"},{"key":"e_1_2_16_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.06.027"},{"key":"e_1_2_16_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-003-0116-1"},{"key":"e_1_2_16_85_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29089"},{"key":"e_1_2_16_86_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2019-106457"},{"key":"e_1_2_16_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.151"},{"key":"e_1_2_16_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del076"},{"key":"e_1_2_16_89_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000497"},{"key":"e_1_2_16_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2362-y"},{"key":"e_1_2_16_91_1","volume-title":"GeneReviews\u00ae [Internet]","author":"Salviati L","year":"1993"},{"key":"e_1_2_16_92_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0800582"},{"key":"e_1_2_16_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.297"},{"key":"e_1_2_16_94_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-96"},{"key":"e_1_2_16_95_1","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20170108"},{"key":"e_1_2_16_96_1","doi-asserted-by":"publisher","DOI":"10.1086\/381653"},{"key":"e_1_2_16_97_1","volume-title":"GeneReviews\u00ae [Internet]","author":"Hirano M","year":"1993"},{"key":"e_1_2_16_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2004.05.009"},{"key":"e_1_2_16_99_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.139"},{"key":"e_1_2_16_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.02.006"},{"key":"e_1_2_16_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.149"},{"key":"e_1_2_16_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.75"},{"key":"e_1_2_16_103_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001345"},{"key":"e_1_2_16_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)80027-3"},{"key":"e_1_2_16_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-013-9614-2"},{"key":"e_1_2_16_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.08.004"},{"key":"e_1_2_16_107_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-591370"},{"key":"e_1_2_16_108_1","doi-asserted-by":"publisher","DOI":"10.1086\/421530"},{"key":"e_1_2_16_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36065"},{"key":"e_1_2_16_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-017-0084-9"},{"key":"e_1_2_16_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.11.029"},{"key":"e_1_2_16_112_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv182"},{"key":"e_1_2_16_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33531"},{"key":"e_1_2_16_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.07.016"},{"key":"e_1_2_16_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-014-9774-8"},{"key":"e_1_2_16_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-018-0156-5"},{"key":"e_1_2_16_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.214"},{"key":"e_1_2_16_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.12.005"},{"key":"e_1_2_16_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35231"},{"key":"e_1_2_16_120_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa064436"},{"key":"e_1_2_16_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12104"},{"key":"e_1_2_16_122_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540110075008"},{"key":"e_1_2_16_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01799112"},{"key":"e_1_2_16_124_1","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20170111"},{"key":"e_1_2_16_125_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2017-105094"},{"key":"e_1_2_16_126_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-019-9292-y"},{"key":"e_1_2_16_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.125"},{"key":"e_1_2_16_128_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.3.598"},{"key":"e_1_2_16_129_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0718"},{"key":"e_1_2_16_130_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003310"},{"key":"e_1_2_16_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.01.027"},{"key":"e_1_2_16_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2897"},{"key":"e_1_2_16_133_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.19-1-30"},{"key":"e_1_2_16_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.09.017"},{"key":"e_1_2_16_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24835"},{"key":"e_1_2_16_136_1","first-page":"151","volume-title":"The quotable Osler","author":"Osler SW","year":"2008"},{"key":"e_1_2_16_137_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.10575"},{"key":"e_1_2_16_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.01.019"},{"key":"e_1_2_16_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.07.007"},{"key":"e_1_2_16_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.07.006"},{"key":"e_1_2_16_141_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2011-100340"},{"key":"e_1_2_16_142_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311660110"},{"key":"e_1_2_16_143_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9120306"},{"key":"e_1_2_16_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.107"},{"key":"e_1_2_16_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12058"},{"key":"e_1_2_16_146_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-311370"},{"key":"e_1_2_16_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2016.04.009"},{"key":"e_1_2_16_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2017.09.009"},{"key":"e_1_2_16_149_1","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20170114"},{"key":"e_1_2_16_150_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20180134"},{"key":"e_1_2_16_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.106546"},{"key":"e_1_2_16_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2019.10.010"},{"key":"e_1_2_16_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25506"},{"key":"e_1_2_16_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0166-8"},{"key":"e_1_2_16_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0165-9"},{"key":"e_1_2_16_156_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000646"},{"key":"e_1_2_16_157_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2018.020"},{"key":"e_1_2_16_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2013"},{"key":"e_1_2_16_159_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws070"},{"key":"e_1_2_16_160_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8312-z"},{"key":"e_1_2_16_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2017.10.003"},{"key":"e_1_2_16_162_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv392"},{"key":"e_1_2_16_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/6772"},{"key":"e_1_2_16_164_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828f1914"},{"key":"e_1_2_16_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24572"},{"key":"e_1_2_16_166_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1399755"}],"container-title":["Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjoim.13054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.13054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joim.13054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joim.13054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T06:25:25Z","timestamp":1693981525000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joim.13054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,7]]},"references-count":165,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/joim.13054"],"URL":"https:\/\/doi.org\/10.1111\/joim.13054","archive":["Portico"],"relation":{},"ISSN":["0954-6820","1365-2796"],"issn-type":[{"value":"0954-6820","type":"print"},{"value":"1365-2796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,7]]},"assertion":[{"value":"2020-04-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}