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Nowadays, it is well known that psychiatric and cognitive complaints are two of the most common, and most distressing, symptoms in patients with CS. Psychiatric symptoms are indeed a major clinical manifestation of CS. The most commonly observed psychiatric conditions are depression and anxiety, whilst mania and psychosis are less common. Several domains of cognitive function are impaired at diagnosis, including episodic and working memory, executive function and attention. Following treatment, one\u2010fourth of the patients still experience depressed mood, and the cognitive impairments are only partially restored. Consequently, quality of life in patients with CS is severely and persistently affected. Neuroimaging studies have also illustrated the deleterious effects of hypercortisolism on the brain by demonstrating reduced grey matter volumes and cortical thickness, altered resting\u2010state functional responses and during cognitive tasks, as well as widespread reduced white matter integrity, especially in structures important for cognitive function and emotional processing, both before and after successful abrogation of hypercortisolism. In this paper, we summarize the current knowledge on the psychiatric and neurocognitive consequences of hypercortisolism in patients with CS, both before, and after successful treatment. In addition, we review the structural and functional brain abnormalities associated with hypercortisolism and discuss the influence of these factors on quality of life.<\/jats:p>","DOI":"10.1111\/joim.13056","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T13:17:47Z","timestamp":1584451067000},"page":"168-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Psychiatric and neurocognitive consequences of endogenous hypercortisolism"],"prefix":"10.1111","volume":"288","author":[{"given":"M.","family":"Piasecka","sequence":"first","affiliation":[{"name":"From the Institute of Medicine at Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Endocrinology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Papakokkinou","sequence":"additional","affiliation":[{"name":"From the Institute of Medicine at Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Endocrinology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Valassi","sequence":"additional","affiliation":[{"name":"IIB\u2010Sant Pau and Department of Endocrinology\/Medicine Hospital Sant Pau Univ Autonoma de Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER\u2010ER, Unidad 747) ISCIII Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Santos","sequence":"additional","affiliation":[{"name":"IIB\u2010Sant Pau and Department of Endocrinology\/Medicine Hospital Sant Pau Univ Autonoma de Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBER\u2010ER, Unidad 747) ISCIII Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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