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The disease caused by SARS\u2010CoV\u20102, coronavirus disease 2019 (COVID\u201019), presents flu\u2010like symptoms which can become serious in high\u2010risk individuals. Here, we provide an overview of the known clinical features and treatment options for COVID\u201019. We carried out a systematic literature search using the main online databases (PubMed, Google Scholar, MEDLINE, UpToDate, Embase and Web of Science) with the following keywords: \u2018COVID\u201019\u2019, \u20182019\u2010nCoV\u2019, \u2018coronavirus\u2019 and \u2018SARS\u2010CoV\u20102\u2019. We included publications from 1 January 2019 to 3 April 2020 which focused on clinical features and treatments. We found that infection is transmitted from human to human and through contact with contaminated environmental surfaces. Hand hygiene is fundamental to prevent contamination. Wearing personal protective equipment is recommended in specific environments. The main symptoms of COVID\u201019 are fever, cough, fatigue, slight dyspnoea, sore throat, headache, conjunctivitis and gastrointestinal issues. Real\u2010time PCR is used as a diagnostic tool using nasal swab, tracheal aspirate or bronchoalveolar lavage samples. Computed tomography findings are important for both diagnosis and follow\u2010up. To date, there is no evidence of any effective treatment for COVID\u201019. The main therapies being used to treat the disease are antiviral drugs, chloroquine\/hydroxychloroquine and respiratory therapy. In conclusion, although many therapies have been proposed, quarantine is the only intervention that appears to be effective in decreasing the contagion rate. Specifically designed randomized clinical trials are needed to determine the most appropriate evidence\u2010based treatment modality.<\/jats:p>","DOI":"10.1111\/joim.13091","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T17:38:10Z","timestamp":1588181890000},"page":"192-206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":965,"title":["COVID\u201019 diagnosis and management: a comprehensive review"],"prefix":"10.1111","volume":"288","author":[{"given":"Giuseppe","family":"Pascarella","sequence":"first","affiliation":[{"name":"Unit of Anaesthesia, Intensive Care and Pain Management Department of Medicine Campus Bio Medico University and Teaching Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3505-1153","authenticated-orcid":false,"given":"Alessandro","family":"Strumia","sequence":"additional","affiliation":[{"name":"Unit 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