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Accumulated evidence from animal models also shows that the metabolic health of the father may influence the metabolic health in his offspring. Vectors for such paternal intergenerational metabolic responses (IGMRs) involve small noncoding RNAs (sncRNAs) that often increase in spermatozoa during the last days of maturation in the epididymis. We and others have shown that the metabolic state \u2013 depending on factors such as diet, obesity and physical exercise \u2013 may affect sperm quality and sperm sncRNA. Together, this suggests that there are overlapping aetiologies between the male metabolic syndrome, male factor infertility and intergenerational responses. In this review, we present a theoretical framework for an overlap of these aetiologies by exploring the advances in our understanding of the roles of sncRNA in spermatogenesis and offspring development. A special focus will lie on novel findings about tRNA\u2010derived small RNA (tsRNA), rRNA\u2010derived small RNA (rsRNA) and small mitochondrial RNA (mitoRNA), and their emerging roles in intergenerational metabolic and reproductive health.<\/jats:p>","DOI":"10.1111\/joim.13096","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T14:46:59Z","timestamp":1589640419000},"page":"305-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Male reproductive health and intergenerational metabolic responses from a small RNA perspective"],"prefix":"10.1111","volume":"288","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9182-9401","authenticated-orcid":false,"given":"D.","family":"N\u00e4tt","sequence":"first","affiliation":[{"name":"From the Department of Clinical and Experimental Medicine Link\u00f6ping University Linkoping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0547-1904","authenticated-orcid":false,"given":"A.","family":"\u00d6st","sequence":"additional","affiliation":[{"name":"From the Department of Clinical and Experimental Medicine Link\u00f6ping University Linkoping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"WHO. 2018 [2020\u201002\u201007]. 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