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Intern. Med."],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Evidence for the association of atrial fibrillation (AF) present on the ECG and cardiovascular outcomes in AF patients is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the prognostic significance of AF on a single surface ECG for cardiovascular outcomes in AF patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 3642 AF patients were prospectively enrolled. Main exclusion criteria were rhythms other than sinus rhythm (SR) or AF. The primary end\u2010point was a composite of all\u2010cause death and hospitalizations for congestive heart failure (CHF). Secondary end\u2010points were all\u2010cause death, CHF hospitalizations, cardiovascular death, myocardial infarction, any stroke and stroke subtypes. Associations were assessed with multivariable Cox proportional hazards models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age was 71\u00a0years, 28% were female, and mean follow\u2010up was 3.4\u00a0years. Patients with SR on the ECG at study enrolment (56%) were younger (69 vs. 74\u00a0years, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), had more often paroxysmal AF (73 vs. 18%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and fewer comorbidities. The incidence of the primary end\u2010point was 1.8 and 3.1 per 100 person\u2010years in patients with SR and AF, respectively. The multivariable\u2010adjusted hazard ratio was 1.4 (95% confidence intervals 1.1; 1.7; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) for patients with AF on the ECG compared to patients with SR. The hazard ratios (95% confidence intervals) were 1.4 (1.1; 1.8; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) for all\u2010cause death, 1.5 (1.2; 1.9; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) for CHF and 1.6 (1.1; 2.2; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) for cardiovascular death. None of the other associations were statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presence of AF in a single office ECG had significant prognostic implications with regard to mortality and CHF hospitalizations in patients with AF. These patients present a high\u2010risk group and might benefit from intensified treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13168","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T08:00:51Z","timestamp":1600070451000},"page":"395-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic significance of present atrial fibrillation on a single office electrocardiogram in patients with atrial fibrillation"],"prefix":"10.1111","volume":"289","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4367-2363","authenticated-orcid":false,"given":"P.","family":"Krisai","sequence":"first","affiliation":[{"name":"From the Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"H\u00e4mmerle","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Blum","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1236-1386","authenticated-orcid":false,"given":"P.","family":"Meyre","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Aeschbacher","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Melchiorre\u2010Mayer","sequence":"additional","affiliation":[{"name":"Department of Cardiology Cardiocentro Ticino Lugano Lugano Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Baretella","sequence":"additional","affiliation":[{"name":"Institute of Primary Health Care (BIHAM) University of Bern Bern Switzerland"},{"name":"Department of General Internal Medicine Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Rodondi","sequence":"additional","affiliation":[{"name":"Institute of Primary Health Care (BIHAM) University of Bern Bern Switzerland"},{"name":"Department of General Internal Medicine Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Conen","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"},{"name":"Population Health Research Institute McMaster University and Hamilton Health Sciences Hamilton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Osswald","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"K\u00fchne","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology University Hospital Basel Basel Switzerland"},{"name":"Cardiovascular Research Institute Basel University Hospital Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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