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Intern. Med."],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The effect of calcium channel blockers (CCB) on mortality and ischaemic stroke risk in dementia patients is understudied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To calculate the risk of death and ischaemic stroke in dementia patients treated with CCBs, considering individual agents and dose response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Longitudinal cohort study with 18\u00a0906 hypertensive dementia patients from the Swedish Dementia Registry (SveDem), 2008\u20132014. Other Swedish national registries contributed information on comorbidities, dispensed medication and outcomes. Individual CCB agents and cumulative defined daily doses (cDDD) were considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients with hypertension and dementia, nifedipine was associated with increased mortality risk (aHR 1.32; CI 1.01\u20131.73;<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05) compared to non\u2010CCB users. Patients diagnosed with Alzheimer\u2019s dementia (AD) or dementia with Lewy bodies\/Parkinson\u2019s disease dementia (DLB\u2010PDD) taking amlodipine had lower mortality risk (aHR, 0.89; CI, 0.80\u20130.98;<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 and aHR 0.58; CI, 0.38\u20130.86;<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01, respectively), than those taking other CCBs. Amlodipine was associated with lower stroke risk in patients with Alzheimer\u2019s dementia compared to other CCBs (aHR 0.63; CI, 0.44\u20130.89;<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><jats:p>Sensitivity analyses with propensity score\u2010matched cohorts repeated the results for nifedipine (aHR 1.35; 95% CI, 1.02\u20131.78;<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and amlodipine in AD (aHR, 0.87; CI, 0.78\u20130.97;<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and DLB\u2010PDD (aHR, 0.56, 95%CI, 0.37\u20130.85;<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Amlodipine was associated with reduced mortality risk in dementia patients diagnosed with AD and DLB\u2010PDD. AD patients using amlodipine had a lower risk of ischaemic stroke compared to other CCB users.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joim.13170","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T14:14:25Z","timestamp":1598624065000},"page":"508-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Calcium channel blockers, survival and ischaemic stroke in patients with dementia: a Swedish registry study"],"prefix":"10.1111","volume":"289","author":[{"given":"I.","family":"Kalar","sequence":"first","affiliation":[{"name":"From the Division of Neurogeriatrics Department of Neurobiology, Care Sciences and Society Karolinska Institutet Stockholm Sweden"},{"name":"Department of Neurology University Medical Centre Ljubljana Ljubljana Slovenia"},{"name":"University of Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7266-3431","authenticated-orcid":false,"given":"H.","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics Department of Neurobiology, Care Sciences and Society Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1532-3967","authenticated-orcid":false,"given":"J.","family":"Secnik","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics Department of Neurobiology, Care Sciences and Society Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5345-7475","authenticated-orcid":false,"given":"E.","family":"Schwertner","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics Department of Neurobiology, Care Sciences and Society Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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