{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:28:46Z","timestamp":1785569326356,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J. Intern. Med."],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Convalescent plasma therapy for COVID\u201019 relies on transfer of anti\u2010viral antibody from donors to recipients via plasma transfusion. The relationship between clinical characteristics and antibody response to COVID\u201019 is not well defined. We investigated predictors of convalescent antibody production and quantified recipient antibody response in a convalescent plasma therapy clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multivariable analysis of clinical and serological parameters in 103 confirmed COVID\u201019 convalescent plasma donors 28\u00a0days or more following symptom resolution was performed. Mixed\u2010effects regression models with piecewise linear trends were used to characterize serial antibody responses in 10 convalescent plasma recipients with severe COVID\u201019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Donor antibody titres ranged from 0 to 1\u00a0:\u00a03892 (anti\u2010receptor binding domain (RBD)) and 0 to 1\u00a0:\u00a03289 (anti\u2010spike). Higher anti\u2010RBD and anti\u2010spike titres were associated with increased age, hospitalization for COVID\u201019, fever and absence of myalgia (all\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Fatigue was significantly associated with anti\u2010RBD (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.03). In pairwise comparison amongst ABO blood types, AB donors had higher anti\u2010RBD and anti\u2010spike than O donors (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). No toxicity was associated with plasma transfusion. Non\u2010ECMO recipient anti\u2010RBD antibody titre increased on average 31% per day during the first three days post\u2010transfusion (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01) and anti\u2010spike antibody titre by 40.3% (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Advanced age, fever, absence of myalgia, fatigue, blood type and hospitalization were associated with higher convalescent antibody titre to COVID\u201019. Despite variability in donor titre, 80% of convalescent plasma recipients showed significant increase in antibody levels post\u2010transfusion. A more complete understanding of the dose\u2010response effect of plasma transfusion amongst COVID\u201019\u2010infected patients is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joim.13185","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T04:16:25Z","timestamp":1602216985000},"page":"559-573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Clinical predictors of donor antibody titre and correlation with recipient antibody response in a COVID\u201019 convalescent plasma clinical trial"],"prefix":"10.1111","volume":"289","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2950-7230","authenticated-orcid":false,"given":"M. L. 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